MBX-1066 | CAS#868971-24-8 | Antibacterial Agent

MedKoo Cat#: 564008 | Name: MBX-1066

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MBX-1066 is a potent antibacterial agent against a wide range of Gram-positive and Gram-negative bacteria.

Chemical Structure

MBX-1066

CAS#868971-24-8 (free base)

Theoretical Analysis

MedKoo Cat#: 564008

Name: MBX-1066

CAS#: 868971-24-8 (free base)

Chemical Formula: C28H24N6

Exact Mass: 444.2062

Molecular Weight: 444.54

Elemental Analysis: C, 75.65; H, 5.44; N, 18.91

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

1429919-10-7 (TFA) 868971-24-8 (free base)

Synonym

MBX-1066; MBX1066; MBX 1066

IUPAC/Chemical Name

6-(4,5-Dihydro-1H-imidazol-2-yl)-2-[4-[6-(4,5-dihydro-1H-imidazol-2-yl)-1H-indol-2-yl]phenyl]-1H-indole

InChi Key

BYXATBRFGOLYAB-UHFFFAOYSA-N

InChi Code

InChI=1S/C28H24N6/c1-2-18(24-14-20-6-8-22(16-26(20)34-24)28-31-11-12-32-28)4-3-17(1)23-13-19-5-7-21(15-25(19)33-23)27-29-9-10-30-27/h1-8,13-16,33-34H,9-12H2,(H,29,30)(H,31,32)

SMILES Code

C(N1)(C2=CC=C(C(N3)=CC4=C3C=C(C5=NCCN5)C=C4)C=C2)=CC6=C1C=C(C7=NCCN7)C=C6

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 444.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Opperman TJ, Kwasny SM, Li JB, Lewis MA, Aiello D, Williams JD, Peet NP, Moir DT, Bowlin TL, Long EC. DNA Targeting as a Likely Mechanism Underlying the Antibacterial Activity of Synthetic Bis-Indole Antibiotics. Antimicrob Agents Chemother. 2016 Nov 21;60(12):7067-7076. Print 2016 Dec. PubMed PMID: 27620482; PubMed Central PMCID: PMC5118985. 2: Williams JD, Nguyen ST, Gu S, Ding X, Butler MM, Tashjian TF, Opperman TJ, Panchal RG, Bavari S, Peet NP, Moir DT, Bowlin TL. Potent and broad-spectrum antibacterial activity of indole-based bisamidine antibiotics: synthesis and SAR of novel analogs of MBX 1066 and MBX 1090. Bioorg Med Chem. 2013 Dec 15;21(24):7790-806. doi: 10.1016/j.bmc.2013.10.014. Epub 2013 Oct 25. PubMed PMID: 24239389; PubMed Central PMCID: PMC3906850.