MedKoo Cat#: 564002 | Name: Cremastranone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cremastranone is a natural antiangiogenic homoisoflavanone. Cremastranone inhibits the proliferation, migration, and tube formation ability of human retinal microvascular endothelial cells.

Chemical Structure

Cremastranone
Cremastranone
CAS#107585-69-3 (racemic)

Theoretical Analysis

MedKoo Cat#: 564002

Name: Cremastranone

CAS#: 107585-69-3 (racemic)

Chemical Formula: C18H18O7

Exact Mass: 346.1053

Molecular Weight: 346.34

Elemental Analysis: C, 62.42; H, 5.24; O, 32.34

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
107585-69-3 (racemic) 142546-12-1 (R-isomer)
Synonym
Cremastranone
IUPAC/Chemical Name
5,7-Dihydroxy-3-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2,3-dihydrochromen-4-one
InChi Key
DSTDMPAJBBOFCE-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H18O7/c1-23-13-4-3-9(6-11(13)19)5-10-8-25-14-7-12(20)18(24-2)17(22)15(14)16(10)21/h3-4,6-7,10,19-20,22H,5,8H2,1-2H3
SMILES Code
O=C1C(CC2=CC=C(OC)C(O)=C2)COC3=C1C(O)=C(OC)C(O)=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 346.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lee B, Basavarajappa HD, Sulaiman RS, Fei X, Seo SY, Corson TW. The first synthesis of the antiangiogenic homoisoflavanone, cremastranone. Org Biomol Chem. 2014 Oct 21;12(39):7673-7. doi: 10.1039/c4ob01604a. Epub 2014 Aug 28. PubMed PMID: 25167470; PubMed Central PMCID: PMC4167916. 2: Sulaiman RS, Basavarajappa HD, Corson TW. Natural product inhibitors of ocular angiogenesis. Exp Eye Res. 2014 Dec;129:161-71. doi: 10.1016/j.exer.2014.10.002. Epub 2014 Oct 7. Review. PubMed PMID: 25304218; PubMed Central PMCID: PMC4259824.