Synonym
Sintropium bromide; VAL 4000; VAL-4000; VAL4000.
IUPAC/Chemical Name
(8r)-3alpha-Hydroxy-8-isopropyl-1alphaH,5alphaH-tropanium bromide 2-propylvalerate
InChi Key
MOOADSDJJYWLMR-VKKQQSAQSA-M
InChi Code
InChI=1S/C19H36NO2.BrH/c1-6-8-15(9-7-2)19(21)22-18-12-16-10-11-17(13-18)20(16,5)14(3)4;/h14-18H,6-13H2,1-5H3;1H/q+1;/p-1/t16-,17+,18-,20+;
SMILES Code
[H][C@]12C[C@@H](OC(C(CCC)CCC)=O)C[C@](CC1)([N@+]2(C(C)C)C)[H].[Br-]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
390.41
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Maritati V, Tanganelli E, Boccardo E, Camandona F, Pietrasanta R, Maganza C, Monti G. [The use of sintropium bromide, a new spasmolytic, in obstetrics and gynecology]. Minerva Ginecol. 1986 Nov;38(11):965-9. Italian. PubMed PMID: 3808432.
2: Bianchi M, Casetti M, Pulvirenti A, Biraghi M. [Sintropium bromide (VAL 480): a new spasmolytic agent in general surgery]. Minerva Chir. 1986 Oct 15;41(19):1661-4. Italian. PubMed PMID: 3808371.
3: Colosi V, Arcidiacono G, Mignosa E, Biraghi M. [Clinical evaluation of a new spasmolytic: sintropium bromide (VAL 480) in spastic states of the upper and lower urinary tract]. Minerva Urol Nefrol. 1986 Jul-Sep;38(3):271-8. Italian. PubMed PMID: 3810389.
4: Norberto L, Sandei F, Monti G. [Instrumental and clinical evaluation of syntropium bromide (VAL 480), a new synthetic spasmolytic]. Minerva Dietol Gastroenterol. 1986 Apr-Jun;32(2):203-7. Italian. PubMed PMID: 3526192.
5: Vinciguerra V, Doronzo F, Tardi S, Vasti MT, Cecere O, Baldassarre G, Palasciano G, Biraghi M. [Echotomographic, colonoscopic and clinical evaluation of syntropium bromide]. Minerva Dietol Gastroenterol. 1986 Apr-Jun;32(2):197-201. Italian. PubMed PMID: 3526191.
6: Galeone M, Cacioli D, Moise G, Bossi M, Benazzi E, Monti G. [The use of syntropium bromide as an antispasmodic]. Minerva Med. 1985 Sep 22;76(36):1605-10. Italian. PubMed PMID: 3900811.
7: Colpi GM, Politi P, Sandri S, Fanciullacci F, Biraghi M, Zanollo A. [Colic and spastic states of the urinary tract. Comparison between syntropium bromide (VAL 480) with ioscine n-butylbromide and with noramidopyrine-pitofenone-fenpiverinium bromide]. Minerva Urol Nefrol. 1985 Jul-Sep;37(3):341-8. Italian. PubMed PMID: 3911456.
