UPGL00004 is a potent inhibitor of glutaminase C (GAC). UPGL00004, like CB-839, more potently inhibits the enzymatic activity of GAC, compared with BPTES. UPGL00004 has a similar binding affinity as CB-839 for GAC. UPGL00004 potently inhibits the growth of triple-negative breast cancer cells, as well as tumor growth when combined with the anti-vascular endothelial growth factor antibody bevacizumab. UPGL00004 occupies the same binding site as CB-839 or BPTES and that all three inhibitors regulate the enzymatic activity of GAC via a similar allosteric mechanism.
MedKoo Cat#: 563913
Name: UPGL00004
CAS#: 1890169-95-5
Chemical Formula: C25H26N8O2S2
Exact Mass: 534.1620
Molecular Weight: 534.66
Elemental Analysis: C, 56.16; H, 4.90; N, 20.96; O, 5.98; S, 11.99
The following data is based on the product molecular weight 534.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
