MedKoo Cat#: 581298 | Name: Desmethyl cariprazine
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Desmethyl Cariprazine Hydrochloride is a derivative of Cariprazine (C183490) which is an orally active D2/D3 dopamine receptor antagonist (1,2,3). Cariprazine is an antipsychotic drug candidate for the potential treatment of schizophrenia, bipolar mania and depression.

Chemical Structure

Desmethyl cariprazine
Desmethyl cariprazine
CAS#839712-15-1 (Desmethyl)

Theoretical Analysis

MedKoo Cat#: 581298

Name: Desmethyl cariprazine

CAS#: 839712-15-1 (Desmethyl)

Chemical Formula: C20H30Cl2N4O

Exact Mass: 412.1797

Molecular Weight: 413.39

Elemental Analysis: C, 58.11; H, 7.32; Cl, 17.15; N, 13.55; O, 3.87

Price and Availability

Size Price Availability Quantity
5mg USD 750.00 2 Weeks
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Synonym
Desmethyl cariprazine; Dcar; UNII-286RCD7025;
IUPAC/Chemical Name
Urea, N-(trans-4-(2-(4-(2,3-dichlorophenyl)-1-piperazinyl)ethyl)cyclohexyl)-N'-methyl-
InChi Key
WMQLLTKSISGWHQ-WKILWMFISA-N
InChi Code
InChI=1S/C20H30Cl2N4O/c1-23-20(27)24-16-7-5-15(6-8-16)9-10-25-11-13-26(14-12-25)18-4-2-3-17(21)19(18)22/h2-4,15-16H,5-14H2,1H3,(H2,23,24,27)/t15-,16-
SMILES Code
O=C(NC)N[C@H]1CC[C@H](CCN2CCN(C3=CC=CC(Cl)=C3Cl)CC2)CC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 413.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Campbell RH, Diduch M, Gardner KN, Thomas C. Review of cariprazine in management of psychiatric illness. Ment Health Clin. 2018 Mar 23;7(5):221-229. doi: 10.9740/mhc.2017.09.221. eCollection 2017 Sep. PubMed PMID: 29955527; PubMed Central PMCID: PMC6007710. 2: Citrome L. Cariprazine for the Treatment of Schizophrenia: A Review of this Dopamine D3-Preferring D3/D2 Receptor Partial Agonist. Clin Schizophr Relat Psychoses. 2016 Summer;10(2):109-19. doi: 10.3371/1935-1232-10.2.109. Review. PubMed PMID: 27440212. 3: Nakamura T, Kubota T, Iwakaji A, Imada M, Kapás M, Morio Y. Clinical pharmacology study of cariprazine (MP-214) in patients with schizophrenia (12-week treatment). Drug Des Devel Ther. 2016 Jan 14;10:327-38. doi: 10.2147/DDDT.S95100. eCollection 2016. PubMed PMID: 26834462; PubMed Central PMCID: PMC4716719. 4: Citrome L. Cariprazine: chemistry, pharmacodynamics, pharmacokinetics, and metabolism, clinical efficacy, safety, and tolerability. Expert Opin Drug Metab Toxicol. 2013 Feb;9(2):193-206. doi: 10.1517/17425255.2013.759211. Review. PubMed PMID: 23320989. 5: Mészáros GP, Agai-Csongor E, Kapás M. Sensitive LC-MS/MS methods for the quantification of RGH-188 and its active metabolites, desmethyl- and didesmethyl-RGH-188 in human plasma and urine. J Pharm Biomed Anal. 2008 Sep 29;48(2):388-97. doi: 10.1016/j.jpba.2007.12.016. Epub 2007 Dec 23. PubMed PMID: 18242914.