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MedKoo Cat#: 563906 | Name: GL-V9

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GL-V9 is an AMPK activator, protecting against colitis-associated colorectal cancer by limiting NLRP3 inflammasome through autophagy.

Chemical Structure

GL-V9
GL-V9
CAS#1178583-19-1

Theoretical Analysis

MedKoo Cat#: 563906

Name: GL-V9

CAS#: 1178583-19-1

Chemical Formula: C24H27NO5

Exact Mass: 409.1889

Molecular Weight: 409.48

Elemental Analysis: C, 70.40; H, 6.65; N, 3.42; O, 19.54

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
GL-V9; GLV9; GL V9
IUPAC/Chemical Name
5-Hydroxy-8-methoxy-2-phenyl-7-(4-(pyrrolidin-1-yl)butoxy)-4H-chromen-4-one
InChi Key
UTBSFLRYDHWNGC-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H27NO5/c1-28-23-21(29-14-8-7-13-25-11-5-6-12-25)16-19(27)22-18(26)15-20(30-24(22)23)17-9-3-2-4-10-17/h2-4,9-10,15-16,27H,5-8,11-14H2,1H3
SMILES Code
O=C1C=C(C2=CC=CC=C2)OC3=C1C(O)=CC(OCCCCN4CCCC4)=C3OC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 409.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yang L, He Z, Yao J, Tan R, Zhu Y, Li Z, Guo Q, Wei L. Regulation of AMPK-related glycolipid metabolism imbalances redox homeostasis and inhibits anchorage independent growth in human breast cancer cells. Redox Biol. 2018 Jul;17:180-191. doi: 10.1016/j.redox.2018.04.016. Epub 2018 Apr 18. PubMed PMID: 29702405; PubMed Central PMCID: PMC6006728. 2: Zhao Y, Guo Q, Zhao K, Zhou Y, Li W, Pan C, Qiang L, Li Z, Lu N. Small molecule GL-V9 protects against colitis-associated colorectal cancer by limiting NLRP3 inflammasome through autophagy. Oncoimmunology. 2017 Sep 21;7(1):e1375640. doi: 10.1080/2162402X.2017.1375640. eCollection 2017. PubMed PMID: 29296531; PubMed Central PMCID: PMC5739552. 3: Zhang X, Kang Y, Huo T, Tao R, Wang X, Li Z, Guo Q, Zhao L. GL-V9 induced upregulation and mitochondrial localization of NAG-1 associates with ROS generation and cell death in hepatocellular carcinoma cells. Free Radic Biol Med. 2017 Nov;112:49-59. doi: 10.1016/j.freeradbiomed.2017.07.011. Epub 2017 Jul 9. PubMed PMID: 28697922. 4: Zhao K, Li G, Yao Y, Zhou Y, Li Z, Guo Q, Lu N. Activation of phospholipase C-γ1 and translocation of phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase contribute to GL-V9-induced apoptosis in human gastric cancer cells. Exp Cell Res. 2017 Jul 1;356(1):8-19. doi: 10.1016/j.yexcr.2017.03.063. Epub 2017 Apr 13. PubMed PMID: 28412247.