MedKoo Cat#: 562698 | Name: SMI-6860766
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

SMI-6860766 is a blocker of CD40-Traf6 interactions. It acts by ameliorating the complications of diet induced obesity in mice.

Chemical Structure

SMI-6860766
CAS#433234-16-3

Theoretical Analysis

MedKoo Cat#: 562698

Name: SMI-6860766

CAS#: 433234-16-3

Chemical Formula: C15H11BrClNO

Exact Mass: 334.9713

Molecular Weight: 336.61

Elemental Analysis: C, 53.52; H, 3.29; Br, 23.74; Cl, 10.53; N, 4.16; O, 4.75

Price and Availability

Size Price Availability Quantity
50mg USD 450.00 2 Weeks
100mg USD 750.00 2 Weeks
200mg USD 1,250.00 2 Weeks
500mg USD 2,650.00 2 Weeks
1g USD 3,650.00 2 Weeks
2g USD 5,850.00 2 Weeks
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Related CAS #
Synonym
SMI-6860766; SMI 6860766; SMI6860766; TRAF-STOP 6860766; TRAFSTOP 6860766; TRAFSTOP6860766; TRAF STOP 6860766;
IUPAC/Chemical Name
(E)-3-((4-bromo-2-chlorophenyl)amino)-1-phenylprop-2-en-1-one
InChi Key
HYNIWWUIOZKCKS-CMDGGOBGSA-N
InChi Code
InChI=1S/C15H11BrClNO/c16-12-6-7-14(13(17)10-12)18-9-8-15(19)11-4-2-1-3-5-11/h1-10,18H/b9-8+
SMILES Code
O=C(/C=C/NC1=C(Cl)C=C(Br)C=C1)C2=CC=CC=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 336.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: van den Berg SM, Seijkens TT, Kusters PJ, Zarzycka B, Beckers L, den Toom M, Gijbels MJ, Chatzigeorgiou A, Weber C, de Winther MP, Chavakis T, Nicolaes GA, Lutgens E. Blocking CD40-TRAF6 interactions by small-molecule inhibitor 6860766 ameliorates the complications of diet-induced obesity in mice. Int J Obes (Lond). 2015 May;39(5):782-90. doi: 10.1038/ijo.2014.198. Epub 2014 Nov 13. PubMed PMID: 25394307.