MedKoo Cat#: 563889 | Name: CM764

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CM764 is a potent and selective antagonist of sigma-2 receptors, a novel derivative of SN79.

Chemical Structure

CM764
CM764
CAS#1350296-29-5

Theoretical Analysis

MedKoo Cat#: 563889

Name: CM764

CAS#: 1350296-29-5

Chemical Formula: C23H27FN4O3

Exact Mass: 426.2067

Molecular Weight: 426.49

Elemental Analysis: C, 64.77; H, 6.38; F, 4.45; N, 13.14; O, 11.25

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CM764; CM-764; CM 764
IUPAC/Chemical Name
6-Acetyl-3-(4-(4-(2-amino-4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one
InChi Key
FYRMUNUDXHUNNW-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H27FN4O3/c1-16(29)17-4-6-21-22(14-17)31-23(30)28(21)9-3-2-8-26-10-12-27(13-11-26)20-7-5-18(24)15-19(20)25/h4-7,14-15H,2-3,8-13,25H2,1H3
SMILES Code
O=C1OC2=CC(C(C)=O)=CC=C2N1CCCCN3CCN(C4=CC=C(F)C=C4N)CC3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 426.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Nicholson H, Mesangeau C, McCurdy CR, Bowen WD. Sigma-2 Receptors Play a Role in Cellular Metabolism: Stimulation of Glycolytic Hallmarks by CM764 in Human SK-N-SH Neuroblastoma. J Pharmacol Exp Ther. 2016 Feb;356(2):232-43. doi: 10.1124/jpet.115.228387. Epub 2015 Nov 16. PubMed PMID: 26574517; PubMed Central PMCID: PMC4746495.