MedKoo Cat#: 581291 | Name: Prothracarcin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Prothracarcin, is a novel antitumor antibiotic. A novel antibiotic, prothracarcin was isolated from the culture broth of Streptomyces umbrosus subsp. It is active against Gram-positive and Gram-negative bacteria and experimental murine tumor sarcoma 180 and leukemia P388.

Chemical Structure

Prothracarcin
Prothracarcin
CAS#81542-99-6

Theoretical Analysis

MedKoo Cat#: 581291

Name: Prothracarcin

CAS#: 81542-99-6

Chemical Formula: C14H14N2O

Exact Mass: 226.1106

Molecular Weight: 226.28

Elemental Analysis: C, 74.31; H, 6.24; N, 12.38; O, 7.07

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Prothracarcin; DC-62; Antibiotic DC 62; UNII-V98H82XQPF;
IUPAC/Chemical Name
(+)-2-Ethylidene-1,2,3,11a-tetrahydro-5H-pyrrolo(2,1-c)(1,4)-benzodiazepin-5-one
InChi Key
GYUDGZRJHSDPLH-WTDSWWLTSA-N
InChi Code
InChI=1S/C14H14N2O/c1-2-10-7-11-8-15-13-6-4-3-5-12(13)14(17)16(11)9-10/h2-6,8,11H,7,9H2,1H3/b10-2+
SMILES Code
O=C1N2C(C/C(C2)=C\C)C=NC3=CC=CC=C13
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 226.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Fotso S, Zabriskie TM, Proteau PJ, Flatt PM, Santosa DA, Mahmud T. Limazepines A-F, pyrrolo[1,4]benzodiazepine Antibiotics from an Indonesian Micrococcus sp. J Nat Prod. 2009 Apr;72(4):690-5. doi: 10.1021/np800827w. Erratum in: J Nat Prod. 2016 Jan 22;79(1):259. PubMed PMID: 19388705. 2: Shimizu K, Kawamoto I, Tomita F, Morimoto M, Fujimoto K. Prothracarcin, a novel antitumor antibiotic. J Antibiot (Tokyo). 1982 Aug;35(8):972-8. PubMed PMID: 7142014.