MedKoo Cat#: 596192 | Name: Protokylol (free base)

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Protokylol (free base) (Asmetil, Caytine, Palison, Ventaire) is a β-adrenergic receptor agonist used as a bronchodilator in Europe and the United States. It is methylenedioxyphenyl-isoproterenol.

Chemical Structure

Protokylol (free base)
Protokylol (free base)
CAS#136-70-9 (free base)

Theoretical Analysis

MedKoo Cat#: 596192

Name: Protokylol (free base)

CAS#: 136-70-9 (free base)

Chemical Formula: C18H21NO5

Exact Mass: 331.1420

Molecular Weight: 331.36

Elemental Analysis: C, 65.24; H, 6.39; N, 4.23; O, 24.14

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Protokylol; JB 251; Protoquilol; Protokylolum; JB-251; JB251;
IUPAC/Chemical Name
4-(2-((1-(benzo[d][1,3]dioxol-5-yl)propan-2-yl)amino)-1-hydroxyethyl)benzene-1,2-diol
InChi Key
LUMAEVHDZXIGEP-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H21NO5/c1-11(6-12-2-5-17-18(7-12)24-10-23-17)19-9-16(22)13-3-4-14(20)15(21)8-13/h2-5,7-8,11,16,19-22H,6,9-10H2,1H3
SMILES Code
CC(NCC(O)C1=CC=C(O)C(O)=C1)CC2=CC(OCO3)=C3C=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 331.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Decker N, Quennedey MC, Rouot B, Schwartz J, Velly J. Effects of N-aralkyl substitution of beta-agonists on alpha- and beta-adrenoceptor subtypes: pharmacological studies and binding assays. J Pharm Pharmacol. 1982 Feb;34(2):107-12. PubMed PMID: 6121868. 2: Dolphin A, Hamont M, Bockaert J. The resolution of dopamine and beta 1- and beta 2-adrenergic-sensitive adenylate cyclase activities in homogenates of cat cerebellum, hippocampus and cerebral cortex. Brain Res. 1979 Dec 28;179(2):305-17. PubMed PMID: 41616. 3: Pecker F, Duvaldestin P, Berthelot P, Hanoune J. The adenylate cyclase system in human liver: characterization, subcellular distribution and hormonal sensitivity in normal or cirrhotic adult, and in foetal liver. Clin Sci (Lond). 1979 Oct;57(4):313-25. PubMed PMID: 41665. 4: Vauquelin G, Geynet P, Hanoune J, Strosberg AD. Affinity chromatography of the beta-adrenergic receptor from turkey erythrocytes. Eur J Biochem. 1979 Aug 1;98(2):543-56. PubMed PMID: 226363. 5: Aggerbeck M, Guellaën G, Hanoune J. N-Aralkyl substitution increases the affinity of adrenergic drugs for the alpha-adrenoceptor in rat liver. Br J Pharmacol. 1979 Jan;65(1):155-9. PubMed PMID: 216448; PubMed Central PMCID: PMC1668481. 6: René E, Lacombe ML, Guellaen G, Hanoune J. [Alteration of the catecholamine receptor during hepatic malignancy (author's transl)]. Ann Endocrinol (Paris). 1976 Mar-Apr;37(2):85-6. French. PubMed PMID: 188380. 7: Saito H, Shudo I. [Micro-fluorescence method for the determination of isoproterenol, protokylol and alpha-methyl dopa]. Nihon Yakurigaku Zasshi. 1972 Jul;68(4):422-8. Japanese. PubMed PMID: 4676298. 8: Saito H, Shudo I. Time course observation on protokylol distribution in rats following protokylol administration. Jpn J Pharmacol. 1972 Feb;22(1):97-102. PubMed PMID: 4537628. 9: Scriabine A, Rival J, Bellet S, Morgan G Jr, Weyn AS, Nusbaum M. Effect of protokylol on the ventricular rate in dogs with experimental A-V heart block. Am Heart J. 1969 May;77(5):649-52. PubMed PMID: 5778054. 10: Chahl LA, O'Donnell SR. The actions of orciprenaline and protokylol on guinea-pig trachea. Br J Pharmacol Chemother. 1968 Jul;33(3):552-9. PubMed PMID: 5728322; PubMed Central PMCID: PMC1570248. 11: KOLLOTZEK H. [CONTRIBUTION ON SYMPTOMATIC THERAPY OF ASTHMA WITH PROTOKYLOL]. Med Klin. 1964 Feb 28;59:345-8. German. PubMed PMID: 14151265. 12: BOTTKE H, GUENTHNER W. [ON THE TREATMENT OF BRONCHIAL OBSTRUCTION. CLINICO-EXPERIMENTAL STUDIES WITH PROTOKYLOL]. Med Welt. 1963 Nov 30;48:2464-9. German. PubMed PMID: 14111042. 13: JACOBI H, KOCH K, SCHLEUSING M. [Contribution to the pharmacology of protokylol]. Ther Ggw. 1963 Feb;102:177-80. German. PubMed PMID: 13964296. 14: JACOBI H, KOCH, SCHLEUSING M. [On the pharmacology of protokylol]. Arzneimittelforschung. 1963 Jan;13:51-6. German. PubMed PMID: 13964297. 15: SARTORELLI E, GRIECO A, MANCOSU M. [Effects of caytine on the respiratory function of asthmatic and emphysematous patients]. Gaz Med Port. 1961 Mar-Apr;14:293-4. Portuguese. PubMed PMID: 14497285. 16: SARTORELLI E, GRIECO A, MANCOSU M. [Effects of caytine on ventilatory function of asthmatics and emphysematous patients]. Clin Ter. 1960 May;18:491-3. Italian. PubMed PMID: 14441828. 17: LESLIE A, SIMMONS DH. Evaluation of the bronchodilator, caytine (JB-251). Am J Med Sci. 1957 Sep;234(3):321-4. PubMed PMID: 13458194. 18: SETTEL E. A new broncholytic drug; JB-251 (caytine). Am Pract Dig Treat. 1957 Aug;8(8):1249-51. PubMed PMID: 13444611.