MedKoo Cat#: 563865 | Name: DPM-1001
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

DPM-1001 is a potent, specific, non-competitive, and orally bioavailable inhibitor of PTP1B, displaying antidiabetic properties associated with enhanced signaling through insulin and leptin receptors in animal models of diet-induced obesity.

Chemical Structure

DPM-1001
DPM-1001
CAS#1471172-27-6

Theoretical Analysis

MedKoo Cat#: 563865

Name: DPM-1001

CAS#: 1471172-27-6

Chemical Formula: C35H57N3O3

Exact Mass: 567.4400

Molecular Weight: 567.86

Elemental Analysis: C, 74.03; H, 10.12; N, 7.40; O, 8.45

Price and Availability

Size Price Availability Quantity
5mg USD 750.00 2 Weeks
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Related CAS #
No Data
Synonym
DPM-1001; DPM1001; DPM 1001
IUPAC/Chemical Name
Methyl (3β,7α)-3-((4-((pyridin-2-ylmethyl)amino)butyl)amino)-7-hydroxycholan-24-oate
InChi Key
RVANDQULNPITCN-DHKCSNTESA-N
InChi Code
InChI=1S/C35H57N3O3/c1-24(10-13-32(40)41-4)28-11-12-29-33-30(15-17-35(28,29)3)34(2)16-14-26(21-25(34)22-31(33)39)37-20-8-7-18-36-23-27-9-5-6-19-38-27/h5-6,9,19,24-26,28-31,33,36-37,39H,7-8,10-18,20-23H2,1-4H3/t24-,25?,26+,28-,29+,30+,31-,33+,34+,35-/m1/s1
SMILES Code
C[C@H](CCC(OC)=O)[C@H]1CC[C@@]2([H])[C@]3([H])[C@H](O)CC4C[C@@H](NCCCCNCC5=NC=CC=C5)CC[C@]4(C)[C@@]3([H])CC[C@]12C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 567.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Krishnan N, Felice C, Rivera K, Pappin DJ, Tonks NK. DPM-1001 decreased copper levels and ameliorated deficits in a mouse model of Wilson's disease. Genes Dev. 2018 Jul 1;32(13-14):944-952. doi: 10.1101/gad.314658.118. Epub 2018 Jun 26. PubMed PMID: 29945887; PubMed Central PMCID: PMC6075031. 2: Krishnan N, Konidaris KF, Gasser G, Tonks NK. A potent, selective, and orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B improves insulin and leptin signaling in animal models. J Biol Chem. 2018 Feb 2;293(5):1517-1525. doi: 10.1074/jbc.C117.819110. Epub 2017 Dec 7. PubMed PMID: 29217773; PubMed Central PMCID: PMC5798283.