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MedKoo Cat#: 563816 | Name: DCZ3301

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DCZ3301 is an aryl-guanidino inhibitor that induces cell apoptosis and cell cycle arrest via suppressing the PI3K/AKT pathway in T-cell leukemia/lymphoma. DCZ3301 induces G2/M cell cycle arrest, and associates with downregulation of CDK1, cyclin B1, and cdc25C. DCZ3301 also induces cell apoptosis by decreasing MMP in T-cell leukemia/lymphoma cells.

Chemical Structure

DCZ3301
DCZ3301
CAS#2136278-38-9

Theoretical Analysis

MedKoo Cat#: 563816

Name: DCZ3301

CAS#: 2136278-38-9

Chemical Formula: C20H16ClF3N6O2

Exact Mass: 464.0975

Molecular Weight: 464.83

Elemental Analysis: C, 51.68; H, 3.47; Cl, 7.63; F, 12.26; N, 18.08; O, 6.88

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
DCZ3301; DCZ3301; DCZ3301
IUPAC/Chemical Name
4-((6-(3-(4-Chloro-3-(trifluoromethyl)phenyl)guanidino)pyridin-3-yl)oxy)-N-methylpicolinamide
InChi Key
XYKDTMNNPVVZPL-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H16ClF3N6O2/c1-26-18(31)16-9-12(6-7-27-16)32-13-3-5-17(28-10-13)30-19(25)29-11-2-4-15(21)14(8-11)20(22,23)24/h2-10H,1H3,(H,26,31)(H3,25,28,29,30)
SMILES Code
O=C(NC)C1=NC=CC(OC2=CC=C(NC(NC3=CC=C(Cl)C(C(F)(F)F)=C3)=N)N=C2)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
DCZ3301 was previosly found to have potent anti-tumor activity in myeloma and B-cell lymphoma. DCZ3301 inhibits the viability of T-cell leukemia/lymphoma cells in a dose- and time-dependent manner.

Preparing Stock Solutions

The following data is based on the product molecular weight 464.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Xiao W, Li B, Sun X, Yu D, Xie Y, Wu H, Chang S, Zhou Y, Wang H, Lan X, Xu Z, Shi J, Zhu W. DCZ3301, a novel aryl-guanidino inhibitor, induces cell apoptosis and cell cycle arrest via suppressing the PI3K/AKT pathway in T-cell leukemia/lymphoma. Acta Biochim Biophys Sin (Shanghai). 2018 Jul 1;50(7):643-650. doi: 10.1093/abbs/gmy047. PubMed PMID: 29688264. 2: Gao M, Li B, Sun X, Zhou Y, Wang Y, Tompkins VS, Xu Z, Indima N, Wang H, Xiao W, Gao L, Chen G, Wu H, Wu X, Kong Y, Xie B, Zhang Y, Chang G, Hu L, Yang G, Dai B, Tao Y, Zhu W, Shi J. Preclinical activity of DCZ3301, a novel aryl-guanidino compound in the therapy of multiple myeloma. Theranostics. 2017 Aug 23;7(15):3690-3699. doi: 10.7150/thno.18345. eCollection 2017. PubMed PMID: 29109769; PubMed Central PMCID: PMC5667341. 3: Sun X, Li B, Xie B, Xu Z, Chang G, Tao Y, Zhang Y, Chang S, Wang Y, Yu D, Xie Y, Li T, Wang H, Chen G, Hu L, Hou J, Zhang Y, Xiao W, Gao L, Shi J, Zhu W. DCZ3301, a novel cytotoxic agent, inhibits proliferation in diffuse large B-cell lymphoma via the STAT3 pathway. Cell Death Dis. 2017 Oct 12;8(10):e3111. doi: 10.1038/cddis.2017.472. PubMed PMID: 29022919; PubMed Central PMCID: PMC5680593.