MedKoo Cat#: 145243 | Name: MD-700

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MD-700 is a novel isobenzofranone. MD-700 at 0.03 microg/ml elevates the expression of LDL receptor in HepG2 cells within 4 h. MD-700 selectively decreases LDL and has very low density lipoprotein cholesterol.

Chemical Structure

MD-700
MD-700
CAS#178759-95-0

Theoretical Analysis

MedKoo Cat#: 145243

Name: MD-700

CAS#: 178759-95-0

Chemical Formula: C24H36O6

Exact Mass: 420.2512

Molecular Weight: 420.55

Elemental Analysis: C, 68.55; H, 8.63; O, 22.83

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
MD-700; MD700; MD 700;
IUPAC/Chemical Name
(R)-3-((R)-13-hydroxy-10-oxotetradecyl)-5,7-dimethoxyisobenzofuran-1(3H)-one
InChi Key
LPYQDDHAJRABQA-DYESRHJHSA-N
InChi Code
1S/C24H36O6/c1-17(25)13-14-18(26)11-9-7-5-4-6-8-10-12-21-20-15-19(28-2)16-22(29-3)23(20)24(27)30-21/h15-17,21,25H,4-14H2,1-3H3/t17-,21-/m1/s1
SMILES Code
COC1=CC2=C(C(=O)O[C@@H]2CCCCCCCCCC(=O)CC[C@@H](C)O)C(OC)=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 420.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Murakami S, Nitanai I, Uchida S, Kondo-Ohta Y, Asami Y, Kondo K, Sato M, Kawashima A, Hara H, Tomisawa K, Mei HB, Xiang CZ. Up-regulation of low density lipoprotein receptor by a novel isobenzofranone derivative, MD-700. Atherosclerosis. 1999 Oct;146(2):281-90. doi: 10.1016/s0021-9150(99)00148-3. PMID: 10532684. 2: Jia Z, Choi J, Park S. Selection of UV-resins for nanostructured molds for thermal-NIL. Nanotechnology. 2018 Sep 7;29(36):365302. doi: 10.1088/1361-6528/aacd33. Epub 2018 Jun 18. PMID: 29911991; PMCID: PMC6532406. 3: Hernández-Castro JA, Li K, Meunier A, Juncker D, Veres T. Fabrication of large-area polymer microfilter membranes and their application for particle and cell enrichment. Lab Chip. 2017 May 31;17(11):1960-1969. doi: 10.1039/c6lc01525e. PMID: 28443860.