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MedKoo Cat#: 555310 | Name: ArgTX-48 TFA

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ArgTX-48 is a highly potent and subfamily selective antagonist of the NMDARs and AMPARs.

Chemical Structure

ArgTX-48 TFA
CAS#1418874-74-4 (TFA)

Theoretical Analysis

MedKoo Cat#: 555310

Name: ArgTX-48 TFA

CAS#: 1418874-74-4 (TFA)

Chemical Formula: C40H62F9N11O14

Exact Mass:

Molecular Weight: 1091.98

Elemental Analysis: C, 44.00; H, 5.72; F, 15.66; N, 14.11; O, 20.51

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
1418874-73-3 (free base) 1418874-74-4 (TFA)
Synonym
ArgTX-48 TFA; ArgTX48; ArgTX 48;
IUPAC/Chemical Name
(S)-N1-(4-((8-((S)-2-amino-5-guanidinopentanamido)octyl)amino)butyl)-2-(2-(2,4-dihydroxyphenyl)acetamido)succinamide tris(2,2,2-trifluoroacetate)
InChi Key
VWHRWOSSRLYAKG-HFYJLKHYSA-N
InChi Code
InChI=1S/C30H53N9O6.3C2HF3O2/c31-23(10-9-17-38-30(33)34)28(44)36-15-6-4-2-1-3-5-13-35-14-7-8-16-37-29(45)24(20-26(32)42)39-27(43)18-21-11-12-22(40)19-25(21)41;3*3-2(4,5)1(6)7/h11-12,19,23-24,35,40-41H,1-10,13-18,20,31H2,(H2,32,42)(H,36,44)(H,37,45)(H,39,43)(H4,33,34,38);3*(H,6,7)/t23-,24-;;;/m0.../s1
SMILES Code
O=C([C@H](CC(N)=O)NC(CC1=CC=C(C=C1O)O)=O)NCCCCNCCCCCCCCNC([C@H](CCCNC(N)=N)N)=O.O=C(C(F)(F)F)O.O=C(C(F)(F)F)O.O=C(C(F)(F)F)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,091.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Nørager NG, Poulsen MH, Jensen AG, Jeppesen NS, Kristensen AS, Strømgaard K. Structure-activity relationship studies of N-methylated and N-hydroxylated spider polyamine toxins as inhibitors of ionotropic glutamate receptors. J Med Chem. 2014 Jun 12;57(11):4940-9. doi: 10.1021/jm5004705. Epub 2014 May 29. PubMed PMID: 24824658.

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