VERU-111, aslo known as ABI-231, is a novel, oral α and β tubulin inhibitor that blocks tubulin polymerization and is not a substrate for multi-drug resistance mechanisms. In xenograft models of taxane responsive and resistant cancers, VERU-111 results in almost complete tumor inhibition at ≤20 mg/kg orally dosed infrequently as 1/week. VERU-111 and docetaxel were tested in the human PCa model, 22Rv1 which expresses androgen receptor splice variants, including AR-V7, and is resistant to abiraterone and enzalutamide.
MedKoo Cat#: 206987
Name: VERU-111
CAS#: 1332881-26-1 (free base)
Chemical Formula: C21H19N3O4
Exact Mass: 377.1376
Molecular Weight: 377.40
Elemental Analysis: C, 66.83; H, 5.07; N, 11.13; O, 16.96
The following data is based on the product molecular weight 377.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
