Synonym
TC E3 5031; TC E3-5031; TC E35031; TCE3 5031; TCE3-5031; TCE35031; TCE 35031; TCE-35031; cereblon ligand 1; Thalidomide-O-COOH; E3 ligase Ligand 3; Thalidomide-Acid
IUPAC/Chemical Name
2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetic acid
InChi Key
ZVWIXIGBWIEDFO-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H12N2O7/c18-10-5-4-8(13(21)16-10)17-14(22)7-2-1-3-9(12(7)15(17)23)24-6-11(19)20/h1-3,8H,4-6H2,(H,19,20)(H,16,18,21)
SMILES Code
O=C(O)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
332.27
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Jelena Bozilovic, Lorenz Eing, Benedict-Tilman Berger, Bikash Adhikari, Janik Weckesser, Nicola B. Berner, Stephanie Wilhelm, Bernhard Kuster, Elmar Wolf, Stefan Knapp,
Novel, highly potent PROTACs targeting AURORA-A kinase,
Current Research in Chemical Biology,
Volume 2, 2022, 100032, ISSN 2666-2469
2. Yamanaka S, Furihata H, Yanagihara Y, Taya A, Nagasaka T, Usui M, Nagaoka K, Shoya Y, Nishino K, Yoshida S, Kosako H, Tanokura M, Miyakawa T, Imai Y, Shibata N, Sawasaki T. Lenalidomide derivatives and proteolysis-targeting chimeras for controlling neosubstrate degradation. Nat Commun. 2023 Aug 18;14(1):4683. doi: 10.1038/s41467-023-40385-9. PMID: 37596276; PMCID: PMC10439208.
