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MedKoo Cat#: 563765 | Name: TC299423

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TC299423 is a novel agonist for nicotinic acetylcholine receptors (nAChRs). TC299423 modestly selectively targets α6β2 subtype.

Chemical Structure

TC299423
TC299423
CAS#1975146-56-5

Theoretical Analysis

MedKoo Cat#: 563765

Name: TC299423

CAS#: 1975146-56-5

Chemical Formula: C11H15N3

Exact Mass: 189.1266

Molecular Weight: 189.26

Elemental Analysis: C, 69.81; H, 7.99; N, 22.20

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
TC299423; TC 299423; TC-299423
IUPAC/Chemical Name
5-Pyrimidin-5-yl-1,2,3,4,7,8-hexahydro-azocine
InChi Key
CRKXSTOXONBMMP-XCVCLJGOSA-N
InChi Code
InChI=1S/C11H15N3/c1-3-10(4-2-6-12-5-1)11-7-13-9-14-8-11/h3,7-9,12H,1-2,4-6H2/b10-3+
SMILES Code
C1(/C2=CN=CN=C2)=C\CCNCCC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 189.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wall TR, Henderson BJ, Voren G, Wageman CR, Deshpande P, Cohen BN, Grady SR, Marks MJ, Yohannes D, Kenny PJ, Bencherif M, Lester HA. TC299423, a Novel Agonist for Nicotinic Acetylcholine Receptors. Front Pharmacol. 2017 Sep 26;8:641. doi: 10.3389/fphar.2017.00641. eCollection 2017. PubMed PMID: 29033834; PubMed Central PMCID: PMC5626944. 2: Post MR, Tender GS, Lester HA, Dougherty DA. Secondary Ammonium Agonists Make Dual Cation-π Interactions in α4β2 Nicotinic Receptors. eNeuro. 2017 Mar 30;4(2). pii: ENEURO.0032-17.2017. doi: 10.1523/ENEURO.0032-17.2017. eCollection 2017 Mar-Apr. PubMed PMID: 28589175; PubMed Central PMCID: PMC5458768. 3: Post MR, Lester HA, Dougherty DA. Probing for and Quantifying Agonist Hydrogen Bonds in α6β2 Nicotinic Acetylcholine Receptors. Biochemistry. 2017 Apr 4;56(13):1836-1840. doi: 10.1021/acs.biochem.7b00213. Epub 2017 Mar 21. PubMed PMID: 28287260; PubMed Central PMCID: PMC6075822. 4: Post MR, Limapichat W, Lester HA, Dougherty DA. Heterologous expression and nonsense suppression provide insights into agonist behavior at α6β2 nicotinic acetylcholine receptors. Neuropharmacology. 2015 Oct;97:376-82. doi: 10.1016/j.neuropharm.2015.04.009. Epub 2015 Apr 20. PubMed PMID: 25908401; PubMed Central PMCID: PMC4635625.