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MedKoo Cat#: 584530 | Name: KS 501

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KS 501 interferes with calmodulin activation and is isolated from Sporothrix sp. KAC-1985.

Chemical Structure

KS 501
KS 501
CAS#120634-86-8

Theoretical Analysis

MedKoo Cat#: 584530

Name: KS 501

CAS#: 120634-86-8

Chemical Formula: C33H48O10

Exact Mass: 604.3247

Molecular Weight: 604.74

Elemental Analysis: C, 65.54; H, 8.00; O, 26.46

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
KS 501; KS501; KS-501
IUPAC/Chemical Name
Benzoic acid, 2-(beta-D-galactofuranosyloxy)-6-heptyl-4-hydroxy-, 3-heptyl-5-hydroxyphenyl ester
InChi Key
MPAXORHHSMKMHV-PPJKYQRASA-N
InChi Code
InChI=1S/C33H48O10/c1-3-5-7-9-11-13-21-15-23(35)18-25(16-21)41-32(40)28-22(14-12-10-8-6-4-2)17-24(36)19-27(28)42-33-30(39)29(38)31(43-33)26(37)20-34/h15-19,26,29-31,33-39H,3-14,20H2,1-2H3/t26-,29-,30-,31+,33-/m1/s1
SMILES Code
O=C(OC1=CC(O)=CC(CCCCCCC)=C1)C2=C(CCCCCCC)C=C(O)C=C2O[C@H]3[C@@H]([C@H]([C@H]([C@@H](CO)O)O3)O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 604.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yasuzawa T, Saitoh Y, Sano H. Structures of KS-501 and KS-502, the new inhibitors of Ca2+ and calmodulin-dependent cyclic nucleotide phosphodiesterase. J Antibiot (Tokyo). 1990 Apr;43(4):336-43. PubMed PMID: 2161817. 2: Hait WN, Gesmonde J, Cheng E. Effects of KS-501, KS-502 and their enantiomers on calmodulin-sensitive enzyme activity and cellular proliferation. Biochem Pharmacol. 1995 Jun 29;50(1):69-74. PubMed PMID: 7605347. 3: Nakanishi S, Ando K, Kawamoto I, Kase H. KS-501 and KS-502, new inhibitors of Ca2+ and calmodulin-dependent cyclic-nucleotide phosphodiesterase from Sporothrix sp. J Antibiot (Tokyo). 1989 Jul;42(7):1049-55. PubMed PMID: 2546910. 4: Bunyapaiboonsri T, Yoiprommarat S, Khonsanit A, Komwijit S. Phenolic glycosides from the filamentous fungus Acremonium sp. BCC 14080. J Nat Prod. 2008 May;71(5):891-4. doi: 10.1021/np070689m. Epub 2008 Mar 26. PubMed PMID: 18363379.

View History

ICI-190622

ICI-190622