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MedKoo Cat#: 533017 | Name: M090

Description:

WARNING: This product is for research use only, not for human or veterinary use.

M090 is a potent inhibitor against amantadine-resistant viruses, including the 2009 H1N1 pandemic strains, and oseltamivir-resistant viruses. M090 targets influenza HA and it occupied a highly conserved pocket of the HA2 domain and inhibited virus-mediated membrane fusion by "locking" the bending state of HA2 during the conformational rearrangement process.

Chemical Structure

M090
M090
CAS#Unknown

Theoretical Analysis

MedKoo Cat#: 533017

Name: M090

CAS#: Unknown

Chemical Formula: C18H28N2

Exact Mass: 272.2252

Molecular Weight: 272.44

Elemental Analysis: C, 79.36; H, 10.36; N, 10.28

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
M090; M-090; M 090.
IUPAC/Chemical Name
(1R,2R,3R,5S)-N-((3-cyclopropyl-1H-pyrrol-2-yl)methyl)-2,6,6-trimethylbicyclo[3.1.1]heptan-3-amine
InChi Key
VQLQHXACIFHRJK-WXYCVUISSA-N
InChi Code
InChI=1S/C18H28N2/c1-11-15-8-13(18(15,2)3)9-16(11)20-10-17-14(6-7-19-17)12-4-5-12/h6-7,11-13,15-16,19-20H,4-5,8-10H2,1-3H3/t11-,13+,15-,16-/m1/s1
SMILES Code
CC1(C)[C@H]2[C@@H](C)[C@H](NCC3=C(C4CC4)C=CN3)C[C@@H]1C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 272.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhao X, Li R, Zhou Y, Xiao M, Ma C, Yang Z, Zeng S, Du Q, Yang C, Jiang H, Hu Y, Wang K, Mok CKP, Sun P, Dong J, Cui W, Wang J, Tu Y, Yang Z, Hu W. Discovery of Highly Potent Pinanamine-Based Inhibitors against Amantadine- and Oseltamivir-Resistant Influenza A Viruses. J Med Chem. 2018 Jun 11. doi: 10.1021/acs.jmedchem.8b00042. [Epub ahead of print] PubMed PMID: 29799746. 2: Ong JJ, Rountrey AN, Zinke J, Meeuwig JJ, Grierson PF, O'Donnell AJ, Newman SJ, Lough JM, Trougan M, Meekan MG. Evidence for climate-driven synchrony of marine and terrestrial ecosystems in northwest Australia. Glob Chang Biol. 2016 Aug;22(8):2776-86. doi: 10.1111/gcb.13239. Epub 2016 Mar 11. PubMed PMID: 26970074. 3: Shackelford N, Renton M, Perring MP, Hobbs RJ. Modeling disturbance-based native invasive species control and its implications for management. Ecol Appl. 2013 Sep;23(6):1331-44. PubMed PMID: 24147406. 4: Larkan NJ, Ruzicka DR, Edmonds-Tibbett T, Durkin JM, Jackson LE, Smith FA, Schachtman DP, Smith SE, Barker SJ. The reduced mycorrhizal colonisation (rmc) mutation of tomato disrupts five gene sequences including the CYCLOPS/IPD3 homologue. Mycorrhiza. 2013 Oct;23(7):573-84. doi: 10.1007/s00572-013-0498-7. Epub 2013 Apr 10. PubMed PMID: 23572326. 5: McLean EH, Ludwig M, Grierson PF. Root hydraulic conductance and aquaporin abundance respond rapidly to partial root-zone drying events in a riparian Melaleuca species. New Phytol. 2011 Nov;192(3):664-75. doi: 10.1111/j.1469-8137.2011.03834.x. Epub 2011 Aug 16. PubMed PMID: 21848988. 6: Abdo DA, Motti CA, Battershill CN, Harvey ES. Temperature and spatiotemporal variability of Salicylihalamide A in the sponge Haliclona sp. J Chem Ecol. 2007 Aug;33(8):1635-45. Epub 2007 Jul 4. PubMed PMID: 17610117. 7: Atkins CA, Smith PM. Translocation in legumes: assimilates, nutrients, and signaling molecules. Plant Physiol. 2007 Jun;144(2):550-61. Review. PubMed PMID: 17556518; PubMed Central PMCID: PMC1914204. 8: McDonald JI, Coupland GT, Kendrick GA. Underwater video as a monitoring tool to detect change in seagrass cover. J Environ Manage. 2006 Jul;80(2):148-55. Epub 2005 Dec 13. PubMed PMID: 16359777. 9: Cullen LE, Macfarlane C. Comparison of cellulose extraction methods for analysis of stable-isotope ratios of carbon and oxygen in plant material. Tree Physiol. 2005 May;25(5):563-69. PubMed PMID: 15741154. 10: Macfarlane C, Hansen LD, Edwards J, White DA, Adams MA. Growth efficiency increases as relative growth rate increases in shoots and roots of Eucalyptus globulus deprived of nitrogen or treated with salt. Tree Physiol. 2005 May;25(5):571-82. PubMed PMID: 15741150. 11: Cawthray GR. An improved reversed-phase liquid chromatographic method for the analysis of low-molecular mass organic acids in plant root exudates. J Chromatogr A. 2003 Sep 5;1011(1-2):233-40. PubMed PMID: 14518781.

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