Synonym
Prodolic acid; NSC 299133; NSC-299133; NSC299133
IUPAC/Chemical Name
Pyrano(3,4-b)indole-1-acetic acid, 1,3,4,9-tetrahydro-1-propyl-
InChi Key
IZGMROSLQHXRDZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H19NO3/c1-2-8-16(10-14(18)19)15-12(7-9-20-16)11-5-3-4-6-13(11)17-15/h3-6,17H,2,7-10H2,1H3,(H,18,19)
SMILES Code
O=C(O)CC1(CCC)OCCC2=C1NC3=C2C=CC=C3
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
273.33
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Robinson WT, Kraml M, Greselin E, Dvornik D. Prodolic acid: analysis and disposition studies in rats and dogs. Xenobiotica. 1977 Jun;7(6):329-37. PubMed PMID: 305689.
2: Greenberg R. Some pharmacological effects of prodolic acid, a new anti-inflammatory compound, indicative of inhibition of prostaglandin synthesis. Can J Physiol Pharmacol. 1975 Feb;53(1):186-9. PubMed PMID: 1139444.
3: Demerson CA, Humber LG, Dobson TA, Martel RR. Chemistry and antiinflammatory activities of prodolic-acid and related 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-alkanoic acids. 1. J Med Chem. 1975 Feb;18(2):189-91. PubMed PMID: 1120985.
4: Martel RR, Klicius J, Herr F. Investigation of 1,3,4,9-Tetrahydro-1-popylpyrano [3,4-b] indole-1-acetic acid (prodolic acid), a new non-steroidal anti-inflammatory agent, in rats. Agents Actions. 1974 Dec;4(5):370-6. PubMed PMID: 4463721.
