Prothipendyl | CAS#303-69-5 | Neuroleptic Azaphenothiazine.

MedKoo Cat#: 593114 | Name: Prothipendyl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Prothipendyl is a neuroleptic azaphenothiazine.

Chemical Structure

Prothipendyl

CAS#303-69-5

Theoretical Analysis

MedKoo Cat#: 593114

Name: Prothipendyl

CAS#: 303-69-5

Chemical Formula: C16H19N3S

Exact Mass: 285.1300

Molecular Weight: 285.41

Elemental Analysis: C, 67.33; H, 6.71; N, 14.72; S, 11.23

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Prothipendyl

IUPAC/Chemical Name

10H-Pyrido(3,2-b)(1,4)benzothiazine, 10-(3-(dimethylamino)propyl)-

InChi Key

JTTAUPUMOLRVRA-UHFFFAOYSA-N

InChi Code

InChI=1S/C16H19N3S/c1-18(2)11-6-12-19-13-7-3-4-8-14(13)20-15-9-5-10-17-16(15)19/h3-5,7-10H,6,11-12H2,1-2H3

SMILES Code

CN(CCCN1C2=NC=CC=C2SC3=CC=CC=C13)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 285.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Caspar AT, Meyer MR, Maurer HH. Blood plasma level determination using an automated LC-MS(n) screening system and electronically stored calibrations exemplified for 22 drugs and two active metabolites often requested in emergency toxicology. Drug Test Anal. 2018 Jul 16. doi: 10.1002/dta.2466. [Epub ahead of print] PubMed PMID: 30011134. 2: Krämer M, Heese P, Banger M, Madea B, Hess C. Range of therapeutic prothipendyl and prothipendyl sulfoxide concentrations in clinical blood samples. Drug Test Anal. 2018 Jun;10(6):1009-1016. doi: 10.1002/dta.2319. Epub 2017 Nov 13. PubMed PMID: 29027369. 3: Krämer M, Broecker S, Madea B, Hess C. Confirmation of metabolites of the neuroleptic drug prothipendyl using human liver microsomes, specific CYP enzymes and authentic forensic samples-Benefit for routine drug testing. J Pharm Biomed Anal. 2017 Oct 25;145:517-524. doi: 10.1016/j.jpba.2017.07.011. Epub 2017 Jul 12. PubMed PMID: 28756170. 4: Paulzen M, Schoretsanitis G, Stegmann B, Hiemke C, Gründer G, Schruers KRJ, Walther S, Lammertz SE, Haen E. Pharmacokinetic considerations in antipsychotic augmentation strategies: How to combine risperidone with low-potency antipsychotics. Prog Neuropsychopharmacol Biol Psychiatry. 2017 Jun 2;76:101-106. doi: 10.1016/j.pnpbp.2017.03.002. Epub 2017 Mar 14. PubMed PMID: 28302501. 5: Morak-Młodawska B, Pluta K, Latocha M, Jeleń M. Synthesis, spectroscopic characterization, and anticancer activity of new 10-substituted 1,6-diazaphenothiazines. Med Chem Res. 2016;25(11):2425-2433. Epub 2016 Aug 4. PubMed PMID: 27818603; PubMed Central PMCID: PMC5075014. 6: Wahl M, Tipotsch-Maca SM, Vecsei-Marlovits PV. Intraoperative floppy iris syndrome and its association with various concurrent medications, bulbus length, patient age and gender. Graefes Arch Clin Exp Ophthalmol. 2017 Jan;255(1):113-118. doi: 10.1007/s00417-016-3515-7. Epub 2016 Oct 19. PubMed PMID: 27761703. 7: Schmedt N, Kollhorst B, Enders D, Jobski K, Krappweis J, Garbe E, Schink T. Comparative risk of death in older adults treated with antipsychotics: A population-based cohort study. Eur Neuropsychopharmacol. 2016 Sep;26(9):1390-1400. doi: 10.1016/j.euroneuro.2016.07.006. Epub 2016 Jul 27. PubMed PMID: 27475994. 8: Yayan J, Rasche K. Treatment Options for Central Sleep Apnea: Comparison of Ventilator, Oxygen, and Drug Therapies. Adv Exp Med Biol. 2016;905:79-86. doi: 10.1007/5584_2015_183. PubMed PMID: 26747067. 9: Mielech-Łukasiewicz K, Staśkowska E. Sensitive and Rapid Voltammetric Determination of Phenothiazine and Azaphenothiazine Derivatives in Pharmaceuticals Using a Boron-doped Diamond Electrode. Anal Sci. 2015;31(10):961-9. doi: 10.2116/analsci.31.961. PubMed PMID: 26460359. 10: Drach LM. [Psychopharmalogical treatment of delirium in the elderly]. Med Monatsschr Pharm. 2014 Apr;37(4):124-31; quiz 133-4. Review. German. PubMed PMID: 24779187. 11: Scharfetter J, Fischer P. [QTc prolongation induced by intravenous sedation with Haloperidol, Prothipendyl and Lorazepam]. Neuropsychiatr. 2014;28(1):1-5. doi: 10.1007/s40211-014-0097-7. Epub 2014 Feb 7. German. PubMed PMID: 24504742. 12: Declercq T, Petrovic M, Azermai M, Vander Stichele R, De Sutter AI, van Driel ML, Christiaens T. Withdrawal versus continuation of chronic antipsychotic drugs for behavioural and psychological symptoms in older people with dementia. Cochrane Database Syst Rev. 2013 Mar 28;(3):CD007726. doi: 10.1002/14651858.CD007726.pub2. Review. PubMed PMID: 23543555. 13: Mann E, Haastert B, Böhmdorfer B, Frühwald T, Iglseder B, Roller-Wirnsberger R, Meyer G. Prevalence and associations of potentially inappropriate prescriptions in Austrian nursing home residents: secondary analysis of a cross-sectional study. Wien Klin Wochenschr. 2013 Apr;125(7-8):180-8. doi: 10.1007/s00508-013-0342-2. Epub 2013 Mar 28. PubMed PMID: 23536016. 14: Pavlic M, Haidekker A, Grubwieser P, Rabl W. Fatal accident caused by isoflurane abuse. Int J Legal Med. 2002 Dec;116(6):357-60. PubMed PMID: 12596784. 15: Misiuk W, Kleszczewska E. Application of ammonium peroxidisulfate and metavanadate for spectrophotometric determination of prothipendyl hydrochloride. Acta Pol Pharm. 2001 Mar-Apr;58(2):87-92. PubMed PMID: 11501795. 16: Schreinzer D, Frey R, Stimpfl T, Vycudilik W, Berzlanovich A, Kasper S. Different fatal toxicity of neuroleptics identified by autopsy. Eur Neuropsychopharmacol. 2001 Apr;11(2):117-24. PubMed PMID: 11313157. 17: Christiaens F, Lessire H, Dellers I, Denis B, Vankeerberghen L, Verborgh C. Successful prolonged cardiopulmonary resuscitation after a combined intoxication with a tricyclic antidepressant, a benzodiazepine and a neuroleptic. Eur J Emerg Med. 2000 Sep;7(3):229-36. PubMed PMID: 11142276. 18: Zed PJ, Loewen PS, Robinson G. Medication-induced headache: overview and systematic review of therapeutic approaches. Ann Pharmacother. 1999 Jan;33(1):61-72. Review. PubMed PMID: 9972386. 19: Michielsen D, Lamberts G, De Boe V, Braeckman J, Keuppens F. Prothipendylhydrochloride-induced priapism: case report. Acta Urol Belg. 1997 Dec;65(4):43-4. PubMed PMID: 9497597. 20: Eberlein-König B, Bindl A, Przybilla B. Phototoxic properties of neuroleptic drugs. Dermatology. 1997;194(2):131-5. PubMed PMID: 9094460.