Dipyridamole tripiperidine | CAS#16982-40-4 |

MedKoo Cat#: 593099 | Name: Dipyridamole tripiperidine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dipyridamole tripiperidine is a biochemical.

Chemical Structure

Dipyridamole tripiperidine

CAS#16982-40-4

Theoretical Analysis

MedKoo Cat#: 593099

Name: Dipyridamole tripiperidine

CAS#: 16982-40-4

Chemical Formula: C25H40N8O2

Exact Mass: 484.3274

Molecular Weight: 484.65

Elemental Analysis: C, 61.96; H, 8.32; N, 23.12; O, 6.60

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Synonym

Dipyridamole tripiperidine

IUPAC/Chemical Name

Ethanol, 2,2'-((4,6,8-tripiperidinopyrimido(5,4-d)pyrimidin-2-yl)imino)di- (7ci,8ci)

InChi Key

QYMDDAUYVDAXDI-UHFFFAOYSA-N

InChi Code

InChI=1S/C25H40N8O2/c34-18-16-33(17-19-35)25-27-21-20(23(29-25)31-12-6-2-7-13-31)26-24(32-14-8-3-9-15-32)28-22(21)30-10-4-1-5-11-30/h34-35H,1-19H2

SMILES Code

OCCN(CCO)C1=NC(N2CCCCC2)=C(N=C(N3CCCCC3)N=C4N5CCCCC5)C4=N1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Dipyridamole tripiperidine is a biochemical.

In vitro activity:

A MTT assay is used to evaluate the proliferation of cancer cells. The addition of dipyridamole (0–20 µM) increased the proliferation of U937 cells, parent HCT-8 cells and the CD133+/CD44+ stem-like subpopulation of HCT-8 cells in a dose-dependent manner (Fig. 1A). Reference: Oncol Lett. 2021 Apr;21(4):251. https://pubmed.ncbi.nlm.nih.gov/33664815/

In vivo activity:

Dipyridamole significantly ameliorated doxorubicin-induced cardiotoxicity in rats, as suggested by the significantly decreased inflammatory mediators TNF-α and IL-6 (Figures 1 and 2). Cardiac tissue level of the oxidative marker MDA significantly decreased (Figure 3) and also significantly increased in TAC (Figure 4) with the dipyridamole group compared to the doxorubicin-only group. Additionally, dipyridamole significantly attenuated doxorubicin-induced apoptosis, reflected by lower cardiac caspase-3 level (Figure 5) and significant elevation in Bcl-2 compared to the doxorubicin-only group (Figure 6). Reference: J Med Life. 2022 Sep;15(9):1184-1190. https://pubmed.ncbi.nlm.nih.gov/36415530/

Preparing Stock Solutions

The following data is based on the product molecular weight 484.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Abdelghany L, El-Mahdy N, Kawabata T, Goto S, Li TS. Dipyridamole induces the phosphorylation of CREB to promote cancer cell proliferation. Oncol Lett. 2021 Apr;21(4):251. doi: 10.3892/ol.2021.12512. Epub 2021 Feb 3. PMID: 33664815; PMCID: PMC7882894. 2. Wang JD, Wang YY, Lin SY, Chang CY, Li JR, Huang SW, Chen WY, Liao SL, Chen CJ. Exosomal HMGB1 Promoted Cancer Malignancy. Cancers (Basel). 2021 Feb 19;13(4):877. doi: 10.3390/cancers13040877. PMID: 33669632; PMCID: PMC7921955. 3. Alyasiry E, Janabi A, Hadi N. Dipyridamole ameliorates doxorubicin-induced cardiotoxicity. J Med Life. 2022 Sep;15(9):1184-1190. doi: 10.25122/jml-2021-0199. PMID: 36415530; PMCID: PMC9635225. 4. Esmaeili S, Azizian S, Shahmoradi B, Moradi S, Shahlaei M, Khodarahmi R. Dipyridamole inhibits α-amylase/α-glucosidase at sub-micromolar concentrations; in-vitro, in-vivo and theoretical studies. Bioorg Chem. 2019 Jul;88:102972. doi: 10.1016/j.bioorg.2019.102972. Epub 2019 May 6. PMID: 31078769.

In vitro protocol:

In vivo protocol:

1. Alyasiry E, Janabi A, Hadi N. Dipyridamole ameliorates doxorubicin-induced cardiotoxicity. J Med Life. 2022 Sep;15(9):1184-1190. doi: 10.25122/jml-2021-0199. PMID: 36415530; PMCID: PMC9635225. 2. Esmaeili S, Azizian S, Shahmoradi B, Moradi S, Shahlaei M, Khodarahmi R. Dipyridamole inhibits α-amylase/α-glucosidase at sub-micromolar concentrations; in-vitro, in-vivo and theoretical studies. Bioorg Chem. 2019 Jul;88:102972. doi: 10.1016/j.bioorg.2019.102972. Epub 2019 May 6. PMID: 31078769.