Synonym
CBiPES hydrochloride; 856702-40-4; DL3XSQ69E9; CBiPES (hydrochloride); UNII-DL3XSQ69E9; CBiPES HCl
IUPAC/Chemical Name
N-(4'-cyano-[1,1'-biphenyl]-3-yl)-N-(pyridin-3-ylmethyl)ethanesulfonamide hydrochloride
InChi Key
QKUHSVQWWZBAKM-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H19N3O2S.ClH/c1-2-27(25,26)24(16-18-5-4-12-23-15-18)21-7-3-6-20(13-21)19-10-8-17(14-22)9-11-19;/h3-13,15H,2,16H2,1H3;1H
SMILES Code
O=S(N(CC2=CC=CN=C2)C1=CC(C3=CC=C(C#N)C=C3)=CC=C1)(CC)=O.Cl
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
413.92
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Frouni I, Kwan C, Nuara SG, Belliveau S, Kang W, Hamadjida A, Bédard D,
Gourdon JC, Huot P. Effect of the mGlu2 positive allosteric modulator
CBiPES on dyskinesia, psychosis-like behaviours and parkinsonism in the MPTP-
lesioned marmoset. J Neural Transm (Vienna). 2021 Jan;128(1):73-81. doi:
10.1007/s00702-020-02287-8. Epub 2021 Jan 3. PMID: 33392826.
2: Benvenga MJ, Chaney SF, Baez M, Britton TC, Hornback WJ, Monn JA, Marek GJ.
Metabotropic Glutamate2 Receptors Play a Key Role in Modulating Head
Twitches Induced by a Serotonergic Hallucinogen in Mice. Front Pharmacol. 2018
Mar 15;9:208. doi: 10.3389/fphar.2018.00208. PMID: 29599719; PMCID: PMC5862811.
3: Caulder EH, Riegle MA, Godwin DW. Activation of group 2 metabotropic
glutamate receptors reduces behavioral and electrographic correlates of
pilocarpine induced status epilepticus. Epilepsy Res. 2014 Feb;108(2):171-81.
doi: 10.1016/j.eplepsyres.2013.10.009. Epub 2013 Nov 16. PMID: 24305700; PMCID:
PMC4378620.
4: Johnson PL, Fitz SD, Engleman EA, Svensson KA, Schkeryantz JM, Shekhar A.
Group II metabotropic glutamate receptor type 2 allosteric potentiators prevent
sodium lactate-induced panic-like response in panic-vulnerable rats. J
Psychopharmacol. 2013 Feb;27(2):152-61. doi: 10.1177/0269881112454230. Epub 2012
Aug 21. PMID: 22914798; PMCID: PMC4300988.
5: Johnson MP, Barda D, Britton TC, Emkey R, Hornback WJ, Jagdmann GE, McKinzie
DL, Nisenbaum ES, Tizzano JP, Schoepp DD. Metabotropic glutamate 2 receptor
potentiators: receptor modulation, frequency-dependent synaptic activity, and
efficacy in preclinical anxiety and psychosis model(s). Psychopharmacology
(Berl). 2005 Apr;179(1):271-83. doi: 10.1007/s00213-004-2099-9. Epub 2005 Feb
17. PMID: 15717213.
