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MedKoo Cat#: 563729 | Name: ADU-S100
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

ADU-S100 is a novel synthetic cyclic dinucleotide that activates the stimulator of IFN genes (STING, or Stimulator of Interferon Genes) pathway.

Chemical Structure

ADU-S100
CAS#1638750-95-4 (sodium)

Theoretical Analysis

MedKoo Cat#: 563729

Name: ADU-S100

CAS#: 1638750-95-4 (sodium)

Chemical Formula: C20H22N10Na2O10P2S2

Exact Mass: 0.0000

Molecular Weight: 734.50

Elemental Analysis: C, 32.71; H, 3.02; N, 19.07; Na, 6.26; O, 21.78; P, 8.43; S, 8.73

Price and Availability

Size Price Availability Quantity
1mg USD 395.00 2 Weeks
5mg USD 1,250.00 2 Weeks
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Related CAS #
1638750-95-4 (sodium) 1638241-89-0 (free acid)
Synonym
ADU-S100; ADU S100; ADUS100; ML RR-S2 CDA sodium salt; MIW815; MIW-815; MIW 815;
IUPAC/Chemical Name
(2',3')-Rp,Rpc-diAMPS disodium
InChi Key
GDWOOOCBNOMMTL-ITQXCAEYSA-L
InChi Code
InChI=1S/C20H24N10O10P2S2.2Na/c21-15-9-17(25-3-23-15)29(5-27-9)19-12(32)13-8(38-19)2-36-42(34,44)40-14-11(31)7(1-35-41(33,43)39-13)37-20(14)30-6-28-10-16(22)24-4-26-18(10)30;;/h3-8,11-14,19-20,31-32H,1-2H2,(H,33,43)(H,34,44)(H2,21,23,25)(H2,22,24,26);;/q;2*+1/p-2/t7-,8-,11-,12-,13-,14-,19-,20-,41-,42-;;/m1../s1
SMILES Code
O[C@@H]1[C@@H](CO[P@@]([S-])(O[C@H]2[C@@H](O)[C@H](N3C4=C(C(N)=NC=N4)N=C3)O[C@@H]2CO5)=O)O[C@@H](N6C7=C(C(N)=NC=N7)N=C6)[C@@H]1O[P@@]5([S-])=O.[Na+].[Na+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 734.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Gountas I, Sypsa V, Blach S, Razavi H, Hatzakis A. HCV elimination among people who inject drugs. Modelling pre- and post-WHO elimination era. PLoS One. 2018 Aug 16;13(8):e0202109. doi: 10.1371/journal.pone.0202109. eCollection 2018. PubMed PMID: 30114207. 2: Razavi-Shearer D, Razavi H. Global prevalence of hepatitis B virus infection and prevention of mother-to-child transmission - Authors' reply. Lancet Gastroenterol Hepatol. 2018 Sep;3(9):599. doi: 10.1016/S2468-1253(18)30199-7. Epub 2018 Aug 8. PubMed PMID: 30102181. 3: Vakharia PP, Chopra R, Silverberg NB, Silverberg JI. Efficacy and Safety of Topical Cantharidin Treatment for Molluscum Contagiosum and Warts: A Systematic Review. Am J Clin Dermatol. 2018 Aug 10. doi: 10.1007/s40257-018-0375-4. [Epub ahead of print] Review. PubMed PMID: 30097988. 4: Cruz-Rojas C, SanJuan-Reyes N, Fuentes-Benites MPAG, Dublan-García O, Galar-Martínez M, Islas-Flores H, Gómez-Oliván LM. Acesulfame potassium: Its ecotoxicity measured through oxidative stress biomarkers in common carp (Cyprinus carpio). Sci Total Environ. 2018 Aug 4;647:772-784. doi: 10.1016/j.scitotenv.2018.08.034. [Epub ahead of print] PubMed PMID: 30096667. 5: Cárdenas-Pérez S, Chanona-Pérez JJ, Güemes-Vera N, Cybulska J, Szymanska-Chargot M, Chylinska M, Kozioł A, Gawkowska D, Pieczywek PM, Zdunek A. Corrigendum to "Structural, mechanical and enzymatic study of pectin and cellulose during mango ripening" [Carbohydr. Polym. 196 (2018) 313-321]. Carbohydr Polym. 2018 Oct 15;198:328. doi: 10.1016/j.carbpol.2018.06.083. Epub 2018 Jun 27. PubMed PMID: 30093006. 6: Scietti L, Chiapparino A, De Giorgi F, Fumagalli M, Khoriauli L, Nergadze S, Basu S, Olieric V, Cucca L, Banushi B, Profumo A, Giulotto E, Gissen P, Forneris F. Molecular architecture of the multifunctional collagen lysyl hydroxylase and glycosyltransferase LH3. Nat Commun. 2018 Aug 8;9(1):3163. doi: 10.1038/s41467-018-05631-5. PubMed PMID: 30089812; PubMed Central PMCID: PMC6082870. 7: Zeng J, Liu H, Rong X, Wang B, Yang Y, Gao X, Wu T, Hong Y. Clinical and radiographic outcomes of cervical disc arthroplasty with Prestige-LP Disc: a minimum 6-year follow-up study. BMC Musculoskelet Disord. 2018 Aug 7;19(1):285. doi: 10.1186/s12891-018-2201-9. PubMed PMID: 30086733; PubMed Central PMCID: PMC6081809. 8: Kaczmarek-Hajek K, Zhang J, Kopp R, Grosche A, Rissiek B, Saul A, Bruzzone S, Engel T, Jooss T, Krautloher A, Schuster S, Magnus T, Stadelmann C, Sirko S, Koch-Nolte F, Eulenburg V, Nicke A. Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody. Elife. 2018 Aug 3;7. pii: e36217. doi: 10.7554/eLife.36217. [Epub ahead of print] PubMed PMID: 30074479. 9: Figueira JSB, Pacheco LB, Lobo I, Volchan E, Pereira MG, de Oliveira L, David IA. "Keep That in Mind!" The Role of Positive Affect in Working Memory for Maintaining Goal-Relevant Information. Front Psychol. 2018 Jul 19;9:1228. doi: 10.3389/fpsyg.2018.01228. eCollection 2018. PubMed PMID: 30072937; PubMed Central PMCID: PMC6060567. 10: De Pieri A, Ribeiro S, Tsiapalis D, Eglin D, Bohner M, Dubruel P, Procter P, Zeugolis DI, Bayon Y. Joint academic and industrial efforts towards innovative and efficient solutions for clinical needs. J Mater Sci Mater Med. 2018 Jul 31;29(8):129. doi: 10.1007/s10856-018-6136-3. Review. PubMed PMID: 30066293. 11: Chen X, Shibata AC, Hendi A, Kurashina M, Fortes E, Weilinger NL, MacVicar BA, Murakoshi H, Mizumoto K. Rap2 and TNIK control Plexin-dependent tiled synaptic innervation in C. elegans. Elife. 2018 Jul 31;7. pii: e38801. doi: 10.7554/eLife.38801. PubMed PMID: 30063210; PubMed Central PMCID: PMC6067881. 12: Tiong KL, Yeang CH. Explaining cancer type specific mutations with transcriptomic and epigenomic features in normal tissues. Sci Rep. 2018 Jul 30;8(1):11456. doi: 10.1038/s41598-018-29861-1. PubMed PMID: 30061703; PubMed Central PMCID: PMC6065413. 13: Ghasemi M, Nolan DR, Lally C. An investigation into the role of different constituents in damage accumulation in arterial tissue and constitutive model development. Biomech Model Mechanobiol. 2018 Jul 30. doi: 10.1007/s10237-018-1054-3. [Epub ahead of print] PubMed PMID: 30058051. 14: Quak M, Langford ZD, London RE, Talsma D. Contralateral delay activity does not reflect behavioral feature load in visual working memory. Biol Psychol. 2018 Jul 25;137:107-115. doi: 10.1016/j.biopsycho.2018.07.006. [Epub ahead of print] PubMed PMID: 30055237. 15: Sturrock M, Miller IS, Kang G, Hannis Arba'ie N, O'Farrell AC, Barat A, Marston G, Coletta PL, Byrne AT, Prehn JH. Anti-angiogenic drug scheduling optimisation with application to colorectal cancer. Sci Rep. 2018 Jul 25;8(1):11182. doi: 10.1038/s41598-018-29318-5. PubMed PMID: 30046049; PubMed Central PMCID: PMC6060139. 16: Cummins MR, Ranade-Kharkar P, Johansen C, Bennett H, Gabriel S, Crouch BI, Del Fiol G, Hoffman M. Simple Workflow Changes Enable Effective Patient Identity Matching in Poison Control. Appl Clin Inform. 2018 Jul;9(3):553-557. doi: 10.1055/s-0038-1667000. Epub 2018 Jul 25. PubMed PMID: 30045385; PubMed Central PMCID: PMC6059864. 17: Chan WK, Wildeboer D, Garelick H, Purchase D. Competition of As and other Group 15 elements for surface binding sites of an extremophilic Acidomyces acidophilus isolated from a historical tin mining site. Extremophiles. 2018 Jul 23. doi: 10.1007/s00792-018-1039-2. [Epub ahead of print] PubMed PMID: 30039469. 18: Grebely J, Larney S, Peacock A, Colledge S, Leung J, Hickman M, Vickerman P, Blach S, Cunningham E, Dumchev K, Lynskey M, Stone J, Trickey A, Razavi H, Mattick RP, Farrell M, Dore GJ, Degenhardt L. Global, regional, and country-level estimates of hepatitis C infection among people who have recently injected drugs. Addiction. 2018 Jul 23. doi: 10.1111/add.14393. [Epub ahead of print] PubMed PMID: 30035835. 19: Zullig LL, Blalock DV, Dougherty S, Henderson R, Ha CC, Oakes MM, Bosworth HB. The new landscape of medication adherence improvement: where population health science meets precision medicine. Patient Prefer Adherence. 2018 Jul 13;12:1225-1230. doi: 10.2147/PPA.S165404. eCollection 2018. Review. PubMed PMID: 30034226; PubMed Central PMCID: PMC6049050. 20: Kerrigan SW, Martin-Loeches I. Public awareness of sepsis is still poor: we need to do more. Intensive Care Med. 2018 Jul 19. doi: 10.1007/s00134-018-5307-5. [Epub ahead of print] PubMed PMID: 30027308.

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NGJ9002

NGJ9002