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MedKoo Cat#: 563720 | Name: HI-346

Description:

WARNING: This product is for research use only, not for human or veterinary use.

HI-346 is a potent inhibitor of multidrug-resistant human immunodeficiency virus-1 (HIV-1).

Chemical Structure

HI-346
HI-346
CAS#149486-68-0

Theoretical Analysis

MedKoo Cat#: 563720

Name: HI-346

CAS#: 149486-68-0

Chemical Formula: C14H18BrN3S

Exact Mass: 339.0405

Molecular Weight: 340.28

Elemental Analysis: C, 49.42; H, 5.33; Br, 23.48; N, 12.35; S, 9.42

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
HI-346; HI 346; HI346;
IUPAC/Chemical Name
1-(5-bromopyridin-2-yl)-3-(2-(cyclohex-1-en-1-yl)ethyl)thiourea
InChi Key
DMUWBIHBABUYBI-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H18BrN3S/c15-12-6-7-13(17-10-12)18-14(19)16-9-8-11-4-2-1-3-5-11/h4,6-7,10H,1-3,5,8-9H2,(H2,16,17,18,19)
SMILES Code
BrC(C=N1)=CC=C1NC(NCCC2=CCCCC2)=S
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 340.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: D'Cruz OJ, Venkatachalam TK, Uckun FM. Novel thiourea compounds as dual-function microbicides. Biol Reprod. 2000 Jul;63(1):196-205. PubMed PMID: 10859260. 2: Uckun FM, Mao C, Pendergrass S, Maher D, Zhu D, Tuel-Ahlgren L, Venkatachalam TK. N-[2-(1-cyclohexenyl)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea and N'-[2-(1-cyclohexenyl)ethyl]-N'-[2-(5-chloropyridyl)]-thiourea as potent inhibitors of multidrug-resistant human immunodeficiency virus-1. Bioorg Med Chem Lett. 1999 Sep 20;9(18):2721-6. PubMed PMID: 10509923.

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