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MedKoo Cat#: 563718 | Name: UCD74A HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

UCD74A HCl is a cell impermeant homolog of UCD38B, inhibitor of uPA (urokinase plasminogen activator).

Chemical Structure

UCD74A HCl
UCD74A HCl
CAS#1345838-99-4

Theoretical Analysis

MedKoo Cat#: 563718

Name: UCD74A HCl

CAS#: 1345838-99-4

Chemical Formula: C8H11Cl2N7O3

Exact Mass: 323.0300

Molecular Weight: 324.12

Elemental Analysis: C, 29.65; H, 3.42; Cl, 21.87; N, 30.25; O, 14.81

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
UCD74A Hydrochloride; UCD74A HCl; UCD-74-A HCl; UCD 74 A HCl;
IUPAC/Chemical Name
N-[6-Amino-5-[[(aminoiminomethyl)amino]carbonyl]-3-chloro-2-pyrazinyl]-glycine hydrochloride
InChi Key
DAXTZYIVXWPBGS-UHFFFAOYSA-N
InChi Code
InChI=1S/C8H10ClN7O3.ClH/c9-4-6(13-1-2(17)18)15-5(10)3(14-4)7(19)16-8(11)12;/h1H2,(H,17,18)(H3,10,13,15)(H4,11,12,16,19);1H
SMILES Code
O=C(O)CNC1=NC(N)=C(C(NC(N)=N)=O)N=C1Cl.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 324.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Leon LJ, Pasupuleti N, Gorin F, Carraway KL 3rd. A cell-permeant amiloride derivative induces caspase-independent, AIF-mediated programmed necrotic death of breast cancer cells. PLoS One. 2013 Apr 30;8(4):e63038. doi: 10.1371/journal.pone.0063038. Print 2013. PubMed PMID: 23646172; PubMed Central PMCID: PMC3639988. 2: Pasupuleti N, Leon L, Carraway KL 3rd, Gorin F. 5-Benzylglycinyl-amiloride kills proliferating and nonproliferating malignant glioma cells through caspase-independent necroptosis mediated by apoptosis-inducing factor. J Pharmacol Exp Ther. 2013 Mar;344(3):600-15. doi: 10.1124/jpet.112.200519. Epub 2012 Dec 14. PubMed PMID: 23241369; PubMed Central PMCID: PMC3583503.