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MedKoo Cat#: 558654 | Name: Methylarsonic acid

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Methylarsonic acid is a herbicide and fungicide on growing cotton and rice.

Chemical Structure

Methylarsonic acid
Methylarsonic acid
CAS#124-58-3

Theoretical Analysis

MedKoo Cat#: 558654

Name: Methylarsonic acid

CAS#: 124-58-3

Chemical Formula: CH5AsO3

Exact Mass: 139.9500

Molecular Weight: 139.97

Elemental Analysis: C, 8.58; H, 3.60; As, 53.53; O, 34.29

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Methylarsonic acid; Kyselina methylarsonova; Methylarsinic acid; Methylarsonic acid;
IUPAC/Chemical Name
Arsonic acid, methyl-
InChi Key
QYPPRTNMGCREIM-UHFFFAOYSA-N
InChi Code
InChI=1S/CH5AsO3/c1-2(3,4)5/h1H3,(H2,3,4,5)
SMILES Code
C[As](O)(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 139.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yoshinaga M, Cai Y, Rosen BP. Demethylation of methylarsonic acid by a microbial community. Environ Microbiol. 2011 May;13(5):1205-15. doi: 10.1111/j.1462-2920.2010.02420.x. Epub 2011 Jan 27. PubMed PMID: 21272184; PubMed Central PMCID: PMC3763196. 2: Guindo Nignan M, Garnier R, Auger J, Ditcharles D, Dossier E, Klein E, Nguyen-Aubier D, Renault B. [Urinary excretion of mineral arsenic, methylarsonic acid and dimethylarsinic acid in workers exposed to gallium arsenide]. J Toxicol Clin Exp. 1992 Oct-Nov;12(4-5):329-31. French. PubMed PMID: 1295988. 3: Wildfang E, Zakharyan RA, Aposhian HV. Enzymatic methylation of arsenic compounds. VI. Characterization of hamster liver arsenite and methylarsonic acid methyltransferase activities in vitro. Toxicol Appl Pharmacol. 1998 Oct;152(2):366-75. PubMed PMID: 9853005. 4: Yamauchi H, Yamamura Y. [Metabolism and excretion of methylarsonic acid]. Sangyo Igaku. 1985 Jan;27(1):40-1. Japanese. PubMed PMID: 4057676. 5: Yamauchi H, Yamato N, Yamamura Y. Metabolism and excretion of orally and intraperitoneally administered methylarsonic acid in the hamster. Bull Environ Contam Toxicol. 1988 Feb;40(2):280-6. PubMed PMID: 3349200. 6: Lario Y, Burló F, Aracil P, Martínez-Romero D, Castillo S, Valero D, Carbonell-Barrachina AA. Methylarsonic and dimethylarsinic acids toxicity and total arsenic accumulation in edible bush beans, Phaseolus vulgaris. Food Addit Contam. 2002 May;19(5):417-26. PubMed PMID: 12028641. 7: Banerjee M, Carew MW, Roggenbeck BA, Whitlock BD, Naranmandura H, Le XC, Leslie EM. A novel pathway for arsenic elimination: human multidrug resistance protein 4 (MRP4/ABCC4) mediates cellular export of dimethylarsinic acid (DMAV) and the diglutathione conjugate of monomethylarsonous acid (MMAIII). Mol Pharmacol. 2014 Aug;86(2):168-79. doi: 10.1124/mol.113.091314. Epub 2014 May 28. PubMed PMID: 24870404. 8: Hata A, Kurosawa H, Endo Y, Yamanaka K, Fujitani N, Endo G. A biological indicator of inorganic arsenic exposure using the sum of urinary inorganic arsenic and monomethylarsonic acid concentrations. J Occup Health. 2016 May 25;58(2):196-200. doi: 10.1539/joh.15-0241-OA. Epub 2016 Mar 24. PubMed PMID: 27010090; PubMed Central PMCID: PMC5356966. 9: Tokar EJ, Kojima C, Waalkes MP. Methylarsonous acid causes oxidative DNA damage in cells independent of the ability to biomethylate inorganic arsenic. Arch Toxicol. 2014 Feb;88(2):249-61. doi: 10.1007/s00204-013-1141-2. Epub 2013 Oct 5. PubMed PMID: 24091636; PubMed Central PMCID: PMC3946729. 10: Calatayud M, Gimeno J, Vélez D, Devesa V, Montoro R. Characterization of the intestinal absorption of arsenate, monomethylarsonic acid, and dimethylarsinic acid using the Caco-2 cell line. Chem Res Toxicol. 2010 Mar 15;23(3):547-56. doi: 10.1021/tx900279e. PubMed PMID: 20078116. 11: Yoshinaga M, Rosen BP. A C⋅As lyase for degradation of environmental organoarsenical herbicides and animal husbandry growth promoters. Proc Natl Acad Sci U S A. 2014 May 27;111(21):7701-6. doi: 10.1073/pnas.1403057111. Epub 2014 May 12. PubMed PMID: 24821808; PubMed Central PMCID: PMC4040596. 12: Chen J, Sun S, Li CZ, Zhu YG, Rosen BP. Biosensor for organoarsenical herbicides and growth promoters. Environ Sci Technol. 2014 Jan 21;48(2):1141-7. doi: 10.1021/es4038319. Epub 2014 Jan 3. PubMed PMID: 24359149; PubMed Central PMCID: PMC3939449. 13: An J, Kim KH, Kim JA, Jung H, Yoon HO, Seo J. A simplified analysis of dimethylarsinic acid by wavelength dispersive X-ray fluorescence spectrometry combined with a strong cation exchange disk. J Hazard Mater. 2013 Sep 15;260:24-31. doi: 10.1016/j.jhazmat.2013.04.033. Epub 2013 Apr 30. PubMed PMID: 23747461. 14: Zhang W, Hu Y, Cheng H. Optimization of microwave-assisted extraction for six inorganic and organic arsenic species in chicken tissues using response surface methodology. J Sep Sci. 2015 Sep;38(17):3063-70. doi: 10.1002/jssc.201500065. Epub 2015 Jul 24. PubMed PMID: 26106064. 15: Ochi T, Nakajima F, Sakurai T, Kaise T, Oya-Ohta Y. Dimethylarsinic acid causes apoptosis in HL-60 cells via interaction with glutathione. Arch Toxicol. 1996;70(12):815-21. PubMed PMID: 8911639. 16: Mester Z, Pawliszyn J. Speciation of dimethylarsinic acid and monomethylarsonic acid by solid-phase microextraction-gas chromatography-ion trap mass spectrometry. J Chromatogr A. 2000 Mar 17;873(1):129-35. PubMed PMID: 10757291. 17: Minakata K, Ohnishi K, Nakamura S, Suzuki M, Suzuki O. Electrospray ionization tandem mass spectrometric determination of monomethylarsonic acid and dimethylarsinic acid after adduct formation with citric acid. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Sep 1;877(25):2624-9. doi: 10.1016/j.jchromb.2009.03.016. Epub 2009 Mar 19. PubMed PMID: 19329367. 18: Miyashita S, Fujiwara S, Tsuzuki M, Kaise T. Rapid biotransformation of arsenate into oxo-arsenosugars by a freshwater unicellular green alga, Chlamydomonas reinhardtii. Biosci Biotechnol Biochem. 2011;75(3):522-30. Epub 2011 Mar 7. PubMed PMID: 21389618. 19: Sampayo-Reyes A, Zakharyan RA, Healy SM, Aposhian HV. Monomethylarsonic acid reductase and monomethylarsonous acid in hamster tissue. Chem Res Toxicol. 2000 Nov;13(11):1181-6. PubMed PMID: 11087441. 20: Moe B, Peng H, Lu X, Chen B, Chen LWL, Gabos S, Li XF, Le XC. Comparative cytotoxicity of fourteen trivalent and pentavalent arsenic species determined using real-time cell sensing. J Environ Sci (China). 2016 Nov;49:113-124. doi: 10.1016/j.jes.2016.10.004. Epub 2016 Oct 24. PubMed PMID: 28007166.

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