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MedKoo Cat#: 592988 | Name: Methylprednisolone sodium succinate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Methylprednisolone sodium succinate is a water-soluble ester of METHYLPREDNISOLONE used for cardiac, allergic, and hypoxic emergencies.

Chemical Structure

Methylprednisolone sodium succinate
Methylprednisolone sodium succinate
CAS#2375-03-3 (sodium)

Theoretical Analysis

MedKoo Cat#: 592988

Name: Methylprednisolone sodium succinate

CAS#: 2375-03-3 (sodium)

Chemical Formula: C26H33NaO8

Exact Mass: 496.2073

Molecular Weight: 496.53

Elemental Analysis: C, 62.89; H, 6.70; Na, 4.63; O, 25.78

Price and Availability

Size Price Availability Quantity
25mg USD 285.00 2 Weeks
250mg USD 950.00 2 Weeks
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Related CAS #
2921-57-5 (free acid) 2375-03-3 (sodium)
Synonym
Methylprednisolone sodium succinate; U 9088; U-9088; U9088
IUPAC/Chemical Name
Pregna-1,4-diene-3,20-dione, 11-beta,17,21-trihydroxy-6-alpha-methyl-, 21- (hydrogen succinate), monosodium salt
InChi Key
FQISKWAFAHGMGT-SGJOWKDISA-M
InChi Code
InChI=1S/C26H34O8.Na/c1-14-10-16-17-7-9-26(33,20(29)13-34-22(32)5-4-21(30)31)25(17,3)12-19(28)23(16)24(2)8-6-15(27)11-18(14)24;/h6,8,11,14,16-17,19,23,28,33H,4-5,7,9-10,12-13H2,1-3H3,(H,30,31);/q;+1/p-1/t14-,16-,17-,19-,23+,24-,25-,26-;/m0./s1
SMILES Code
O=C([O-])CCC(OCC([C@@](O)(CC1)[C@](C[C@H](O)[C@@H]2[C@@]3(C)C=C4)(C)[C@@H]1[C@@H]2C[C@H](C)C3=CC4=O)=O)=O.[Na+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Methylprednisolone succinate (Methylprednisolone hydrogen succinate) sodium is a glucocorticoid of slightly longer half-life than that of Prednisolone.
In vitro activity:
In addition to its potent anti-inflammatory and antioxidant properties, this study recently discovered a selective antiapoptotic effect of MP (methylprednisone) on oligodendrocytes via the activation of the glucocorticoid receptor (GR) and the upregulation of bcl-X(L), a splicing isoform of the bcl-x gene. The GR and STAT5 complex is present on the STAT5-binding site of the bcl-x promoter region in oligodendrocytes; the overexpression of an activated form of STAT5 prevents alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-induced oligodendrocyte cell death; and this prevention is lost when the STAT5 gene is knocked down. Reference: J Neurosci. 2009 Feb 18;29(7):2022-6. https://pubmed.ncbi.nlm.nih.gov/19228956/
In vivo activity:
This study investigated the effect of MPSS (methylprednisolone sodium succinate) on inflammation and disruption of the BBB (blood-brain barrier) in a model mouse of ICH (intracranial hemorrhage). Administration of MPSS post-ICH significantly reduced permeability of the BBB and brain oedema and upregulated expression of ZO-1 and Occludin. MPSS inhibited inflammatory responses, including reducing proinflammatory cytokines (IL-1β, TNF-α), suppressing infiltration of neutrophils and activation of microglia. Reference: Brain Res Bull. 2016 Oct;127:226-233. https://pubmed.ncbi.nlm.nih.gov/27746369/
Solvent mg/mL mM comments
Solubility
DMF 10.0 20.14
DMSO 43.0 86.60
Ethanol 99.0 199.38
PBS (pH 7.2) 3.0 6.04
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 496.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Xu J, Chen S, Chen H, Xiao Q, Hsu CY, Michael D, Bao J. STAT5 mediates antiapoptotic effects of methylprednisolone on oligodendrocytes. J Neurosci. 2009 Feb 18;29(7):2022-6. doi: 10.1523/JNEUROSCI.2621-08.2009. PMID: 19228956; PMCID: PMC2662324. 2. Diem R, Hobom M, Maier K, Weissert R, Storch MK, Meyer R, Bähr M. Methylprednisolone increases neuronal apoptosis during autoimmune CNS inflammation by inhibition of an endogenous neuroprotective pathway. J Neurosci. 2003 Aug 6;23(18):6993-7000. doi: 10.1523/JNEUROSCI.23-18-06993.2003. PMID: 12904460; PMCID: PMC6740669. 3. Cheng S, Gao W, Xu X, Fan H, Wu Y, Li F, Zhang J, Zhu X, Zhang Y. Methylprednisolone sodium succinate reduces BBB disruption and inflammation in a model mouse of intracranial haemorrhage. Brain Res Bull. 2016 Oct;127:226-233. doi: 10.1016/j.brainresbull.2016.10.007. Epub 2016 Oct 13. PMID: 27746369. 4. Oudega M, Vargas CG, Weber AB, Kleitman N, Bunge MB. Long-term effects of methylprednisolone following transection of adult rat spinal cord. Eur J Neurosci. 1999 Jul;11(7):2453-64. doi: 10.1046/j.1460-9568.1999.00666.x. PMID: 10383635.
In vitro protocol:
1. Xu J, Chen S, Chen H, Xiao Q, Hsu CY, Michael D, Bao J. STAT5 mediates antiapoptotic effects of methylprednisolone on oligodendrocytes. J Neurosci. 2009 Feb 18;29(7):2022-6. doi: 10.1523/JNEUROSCI.2621-08.2009. PMID: 19228956; PMCID: PMC2662324. 2. Diem R, Hobom M, Maier K, Weissert R, Storch MK, Meyer R, Bähr M. Methylprednisolone increases neuronal apoptosis during autoimmune CNS inflammation by inhibition of an endogenous neuroprotective pathway. J Neurosci. 2003 Aug 6;23(18):6993-7000. doi: 10.1523/JNEUROSCI.23-18-06993.2003. PMID: 12904460; PMCID: PMC6740669.
In vivo protocol:
1. Cheng S, Gao W, Xu X, Fan H, Wu Y, Li F, Zhang J, Zhu X, Zhang Y. Methylprednisolone sodium succinate reduces BBB disruption and inflammation in a model mouse of intracranial haemorrhage. Brain Res Bull. 2016 Oct;127:226-233. doi: 10.1016/j.brainresbull.2016.10.007. Epub 2016 Oct 13. PMID: 27746369. 2. Oudega M, Vargas CG, Weber AB, Kleitman N, Bunge MB. Long-term effects of methylprednisolone following transection of adult rat spinal cord. Eur J Neurosci. 1999 Jul;11(7):2453-64. doi: 10.1046/j.1460-9568.1999.00666.x. PMID: 10383635.
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PubMed PMID: 29692212; PubMed Central PMCID: PMC5961923. 4: Desu HR, Thoma LA, Wood GC. Nebulization of Cyclic Arginine-Glycine-(D)-Aspartic Acid-Peptide Grafted and Drug Encapsulated Liposomes for Inhibition of Acute Lung Injury. Pharm Res. 2018 Mar 13;35(5):94. doi: 10.1007/s11095-018-2366-9. PubMed PMID: 29536186. 5: Hu P, Mao Z, Liu C, Hu X, Kang H, Zhou F. Malignant atrophic papulosis with motor aphasia and intestinal perforation: A case report and review of published works. J Dermatol. 2018 Jun;45(6):723-726. doi: 10.1111/1346-8138.14280. Epub 2018 Mar 8. PubMed PMID: 29516548; PubMed Central PMCID: PMC6001538. 6: Morrow SA, Fraser JA, Day C, Bowman D, Rosehart H, Kremenchutzky M, Nicolle M. Effect of Treating Acute Optic Neuritis With Bioequivalent Oral vs Intravenous Corticosteroids: A Randomized Clinical Trial. JAMA Neurol. 2018 Jun 1;75(6):690-696. doi: 10.1001/jamaneurol.2018.0024. PubMed PMID: 29507942; PubMed Central PMCID: PMC5885218. 7: Kanhai KMS, Zuiker RGJA, Stavrakaki I, Gladdines W, Gaillard PJ, Klaassen ES, Groeneveld GJ. Glutathione-PEGylated liposomal methylprednisolone in comparison to free methylprednisolone: slow release characteristics and prolonged lymphocyte depression in a first-in-human study. Br J Clin Pharmacol. 2018 May;84(5):1020-1028. doi: 10.1111/bcp.13525. Epub 2018 Mar 9. PubMed PMID: 29385232; PubMed Central PMCID: PMC5903232. 8: Sámano C, Nistri A. Mechanism of Neuroprotection Against Experimental Spinal Cord Injury by Riluzole or Methylprednisolone. Neurochem Res. 2017 Dec 30. doi: 10.1007/s11064-017-2459-6. [Epub ahead of print] PubMed PMID: 29290040. 9: Fehlings MG, Tetreault LA, Wilson JR, Kwon BK, Burns AS, Martin AR, Hawryluk G, Harrop JS. A Clinical Practice Guideline for the Management of Acute Spinal Cord Injury: Introduction, Rationale, and Scope. Global Spine J. 2017 Sep;7(3 Suppl):84S-94S. doi: 10.1177/2192568217703387. Epub 2017 Sep 5. PubMed PMID: 29164036; PubMed Central PMCID: PMC5684846. 10: Fehlings MG, Kwon BK, Tetreault LA. Guidelines for the Management of Degenerative Cervical Myelopathy and Spinal Cord Injury: An Introduction to a Focus Issue. Global Spine J. 2017 Sep;7(3 Suppl):6S-7S. doi: 10.1177/2192568217701714. Epub 2017 Sep 5. PubMed PMID: 29164034; PubMed Central PMCID: PMC5684836. 11: Fehlings MG, Wilson JR, Tetreault LA, Aarabi B, Anderson P, Arnold PM, Brodke DS, Burns AS, Chiba K, Dettori JR, Furlan JC, Hawryluk G, Holly LT, Howley S, Jeji T, Kalsi-Ryan S, Kotter M, Kurpad S, Kwon BK, Marino RJ, Martin AR, Massicotte E, Merli G, Middleton JW, Nakashima H, Nagoshi N, Palmieri K, Skelly AC, Singh A, Tsai EC, Vaccaro A, Yee A, Harrop JS. A Clinical Practice Guideline for the Management of Patients With Acute Spinal Cord Injury: Recommendations on the Use of Methylprednisolone Sodium Succinate. Global Spine J. 2017 Sep;7(3 Suppl):203S-211S. doi: 10.1177/2192568217703085. Epub 2017 Sep 5. PubMed PMID: 29164025; PubMed Central PMCID: PMC5686915. 12: Fehlings MG, Wilson JR, Harrop JS, Kwon BK, Tetreault LA, Arnold PM, Singh JM, Hawryluk G, Dettori JR. Efficacy and Safety of Methylprednisolone Sodium Succinate in Acute Spinal Cord Injury: A Systematic Review. Global Spine J. 2017 Sep;7(3 Suppl):116S-137S. doi: 10.1177/2192568217706366. Epub 2017 Sep 5. Review. PubMed PMID: 29164020; PubMed Central PMCID: PMC5684849. 13: Schlatter J, Nguyen D, Zamy M, Kabiche S, Fontan JE, Cisternino S. Safety of intrathecal route: focus to methylprednisolone acetate (Depo-Medrol) use. Eur Spine J. 2017 Nov 18. doi: 10.1007/s00586-017-5387-x. [Epub ahead of print] Review. PubMed PMID: 29151132. 14: Porcaro F, Paglietti MG, Diamanti A, Petreschi F, Schiavino A, Negro V, Pecora V, Fiocchi A, Cutrera R. Anaphylactic shock with methylprednisolone sodium succinate in a child with short bowel syndrome and cow's milk allergy. 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