MedKoo Cat#: 558636 | Name: Hydroxyacetic acid
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Hydroxyacetic acid is a dermatologic agent. It has also been used as a plant-tissue based biosensor and chemiluminescence flow sensor.

Chemical Structure

Hydroxyacetic acid
Hydroxyacetic acid
CAS#79-14-1

Theoretical Analysis

MedKoo Cat#: 558636

Name: Hydroxyacetic acid

CAS#: 79-14-1

Chemical Formula: C2H4O3

Exact Mass: 76.0200

Molecular Weight: 76.05

Elemental Analysis: C, 31.59; H, 5.30; O, 63.11

Price and Availability

Size Price Availability Quantity
25g USD 250.00 2 Weeks
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Related CAS #
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Synonym
Hydroxyacetic acid; Hydroxyethanoic acid; Glycolic acid; Glycollic acid;
IUPAC/Chemical Name
Acetic acid, 2-hydroxy-
InChi Key
AEMRFAOFKBGASW-UHFFFAOYSA-N
InChi Code
InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)
SMILES Code
O=C(O)CO
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 76.05 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Mekas M, Chwalek J, MacGregor J, Chapas A. An Evaluation of Efficacy and Tolerability of Novel Enzyme Exfoliation Versus Glycolic Acid in Photodamage Treatment. J Drugs Dermatol. 2015 Nov;14(11):1306-19. PubMed PMID: 26580881. 2: Sarkar R, Garg V, Bansal S, Sethi S, Gupta C. Comparative Evaluation of Efficacy and Tolerability of Glycolic Acid, Salicylic Mandelic Acid, and Phytic Acid Combination Peels in Melasma. Dermatol Surg. 2016 Mar;42(3):384-91. doi: 10.1097/DSS.0000000000000642. PubMed PMID: 26859648. 3: Li BL, Zhang ZG, Du LL, Wang W. Chiral resolutions of (9-anthryl)methoxyacetic acid and (9-anthryl)hydroxyacetic acid by capillary electrophoresis. Chirality. 2008 Jan;20(1):35-9. PubMed PMID: 17960539. 4: Ibrahim ZA, Gheida SF, El Maghraby GM, Farag ZE. Evaluation of the efficacy and safety of combinations of hydroquinone, glycolic acid, and hyaluronic acid in the treatment of melasma. J Cosmet Dermatol. 2015 Jun;14(2):113-23. doi: 10.1111/jocd.12143. Epub 2015 Apr 6. PubMed PMID: 25847063. 5: Prestes PS, Oliveira MM, Leonardi GR. Randomized clinical efficacy of superficial peeling with 85% lactic acid versus 70% glycolic acid. An Bras Dermatol. 2013 Nov-Dec;88(6):900-5. doi: 10.1590/abd1806-4841.20131888. PubMed PMID: 24474097; PubMed Central PMCID: PMC3900339. 6: Koivistoinen OM, Kuivanen J, Barth D, Turkia H, Pitkänen JP, Penttilä M, Richard P. Glycolic acid production in the engineered yeasts Saccharomyces cerevisiae and Kluyveromyces lactis. Microb Cell Fact. 2013 Sep 23;12:82. doi: 10.1186/1475-2859-12-82. PubMed PMID: 24053654; PubMed Central PMCID: PMC3850452. 7: Osman NI, Roman S, Bullock AJ, Chapple CR, MacNeil S. The effect of ascorbic acid and fluid flow stimulation on the mechanical properties of a tissue engineered pelvic floor repair material. Proc Inst Mech Eng H. 2014 Sep;228(9):867-75. doi: 10.1177/0954411914549393. PubMed PMID: 25313023. 8: Hashim P. The effect of Centella asiatica, vitamins, glycolic acid and their mixtures preparations in stimulating collagen and fibronectin synthesis in cultured human skin fibroblast. Pak J Pharm Sci. 2014 Mar;27(2):233-7. PubMed PMID: 24577907. 9: Takenaka Y, Hayashi N, Takeda M, Ashikaga S, Kawashima M. Glycolic acid chemical peeling improves inflammatory acne eruptions through its inhibitory and bactericidal effects on Propionibacterium acnes. J Dermatol. 2012 Apr;39(4):350-4. doi: 10.1111/j.1346-8138.2011.01321.x. Epub 2011 Sep 28. PubMed PMID: 21950544. 10: Pereañez JA, Patiño AC, Rey-Suarez P, Núñez V, Henao Castañeda IC, Rucavado A. Glycolic acid inhibits enzymatic, hemorrhagic and edema-inducing activities of BaP1, a P-I metalloproteinase from Bothrops asper snake venom: insights from docking and molecular modeling. Toxicon. 2013 Sep;71:41-8. doi: 10.1016/j.toxicon.2013.05.013. Epub 2013 May 30. PubMed PMID: 23726855. 11: Maia Campos PM, Gaspar LR, Gonçalves GM, Pereira LH, Semprini M, Lopes RA. Comparative effects of retinoic acid or glycolic acid vehiculated in different topical formulations. Biomed Res Int. 2015;2015:650316. doi: 10.1155/2015/650316. Epub 2015 Jan 6. PubMed PMID: 25632398; PubMed Central PMCID: PMC4302967. 12: Guo R, Chai W, Rideout JM, Lawson AM, Lim CK. Isolation and characterization of beta-hydroxypropionic acid- and hydroxyacetic acid-uroporphyrin I in the urine of a patient with congenital erythropoietic porphyria by high performance liquid chromatography and liquid secondary ion mass spectrometry. Biomed Chromatogr. 1990 Jul;4(4):141-3. PubMed PMID: 2207373. 13: Zhang H, Shi L, Mao X, Lin J, Wei D. Enhancement of cell growth and glycolic acid production by overexpression of membrane-bound alcohol dehydrogenase in Gluconobacter oxydans DSM 2003. J Biotechnol. 2016 Nov 10;237:18-24. doi: 10.1016/j.jbiotec.2016.09.003. Epub 2016 Sep 9. PubMed PMID: 27619641. 14: Manabe N, Kirikoshi R, Takahashi O. Glycolic acid-catalyzed deamidation of asparagine residues in degrading PLGA matrices: a computational study. Int J Mol Sci. 2015 Mar 31;16(4):7261-72. doi: 10.3390/ijms16047261. PubMed PMID: 25837471; PubMed Central PMCID: PMC4425015. 15: Hložek T, Bursová M, Čabala R. Simultaneous and cost-effective determination of ethylene glycol and glycolic acid in human serum and urine for emergency toxicology by GC-MS. Clin Biochem. 2015 Feb;48(3):189-91. doi: 10.1016/j.clinbiochem.2014.12.002. Epub 2014 Dec 10. PubMed PMID: 25500419. 16: Chaudhary S, Dayal S. Efficacy of combination of glycolic acid peeling with topical regimen in treatment of melasma. J Drugs Dermatol. 2013 Oct;12(10):1149-53. PubMed PMID: 24085051. 17: Gao X, Ma Z, Yang L, Ma J. Enhanced bioconversion of ethylene glycol to glycolic acid by a newly isolated Burkholderia sp. EG13. Appl Biochem Biotechnol. 2014 Oct;174(4):1572-1580. doi: 10.1007/s12010-014-1114-9. Epub 2014 Aug 16. PubMed PMID: 25123362. 18: Ellis-Hutchings RG, Moore NP, Marshall VA, Rasoulpour RJ, Carney EW. Disposition of glycolic acid into rat and rabbit embryos in vitro. Reprod Toxicol. 2014 Jul;46:46-55. doi: 10.1016/j.reprotox.2014.02.005. Epub 2014 Mar 2. PubMed PMID: 24598581. 19: Casalini T, Rossi F, Santoro M, Perale G. Structural characterization of poly-l-lactic acid (P(L)LA) and poly(glycolic acid)(PGA) oligomers. Int J Mol Sci. 2011;12(6):3857-70. doi: 10.3390/ijms12063857. Epub 2011 Jun 10. PubMed PMID: 21747712; PubMed Central PMCID: PMC3131596. 20: Sharad J. Combination of microneedling and glycolic acid peels for the treatment of acne scars in dark skin. J Cosmet Dermatol. 2011 Dec;10(4):317-23. doi: 10.1111/j.1473-2165.2011.00583.x. PubMed PMID: 22151943.