Arotinolol hydrochloride | CAS#68377-91-3 | mixed alpha/beta blocker

MedKoo Cat#: 592960 | Name: Arotinolol hydrochloride

Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Arotinolol (INN, marketed under the tradename Almarl) is a medication in the class of mixed alpha/beta blockers. It also acts as a β3 receptor agonist. A 1979 publication suggests arotinolol as having first been described in the scientific literature by Sumitomo Chemical as "β-adrenergic blocking, antiarrhythmic compound S-596".

Chemical Structure

Arotinolol hydrochloride

CAS#68377-91-3 (HCl)

Theoretical Analysis

MedKoo Cat#: 592960

Name: Arotinolol hydrochloride

CAS#: 68377-91-3 (HCl)

Chemical Formula: C15H22ClN3O2S3

Exact Mass: 407.0563

Molecular Weight: 407.99

Elemental Analysis: C, 44.16; H, 5.44; Cl, 8.69; N, 10.30; O, 7.84; S, 23.57

Price and Availability

Size	Price	Availability	Quantity
100mg	USD 450.00	2 Weeks
250mg	USD 850.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

68377-92-4 (free base) 68377-91-3 (HCl) 87055-50-3 (R-isomer HCl) 92075-58-6 (R-isomer) 101540-26-5 (S-isomer HCl)

Synonym

Arotinolol hydrochloride; Arotinolol HCl,

IUPAC/Chemical Name

2-Thiophenecarboxamide, 5-(2-((3-((1,1-dimethylethyl)amino)-2-hydroxypropyl)thio)-4-thiazolyl)-, monohydrochloride, (+-)-

InChi Key

XXDAXBZYUXLDRD-UHFFFAOYSA-N

InChi Code

InChI=1S/C15H21N3O2S3.ClH/c1-15(2,3)17-6-9(19)7-21-14-18-10(8-22-14)11-4-5-12(23-11)13(16)20;/h4-5,8-9,17,19H,6-7H2,1-3H3,(H2,16,20);1H

SMILES Code

O=C(C1=CC=C(C2=CSC(SCC(O)CNC(C)(C)C)=N2)S1)N.[H]Cl

Appearance

Solid powder

Purity

>97% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 407.99 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Wang Z, Zhang X, Jiang S, Guo X. Magnetic solid-phase extraction based on magnetic multiwalled carbon nanotubes for the simultaneous enantiomeric analysis of five β-blockers in the environmental samples by chiral liquid chromatography coupled with tandem mass spectrometry. Talanta. 2018 Apr 1;180:98-107. doi: 10.1016/j.talanta.2017.12.034. Epub 2017 Dec 14. PubMed PMID: 29332839. 2: Qian Z, Le J, Chen X, Li S, Song H, Hong Z. High-throughput LC-MS/MS method with 96-well plate precipitation for the determination of arotinolol and amlodipine in a small volume of rat plasma: Application to a pharmacokinetic interaction study. J Sep Sci. 2018 Feb;41(3):618-629. doi: 10.1002/jssc.201700784. Epub 2017 Dec 11. PubMed PMID: 29115741. 3: Fang L, Du Y, Hu X, Luo L, Guo X, Guo X, Yu J. Carboxymethyl β-cyclodextrin as chiral selector in capillary electrophoresis: Enantioseparation of 16 basic chiral drugs and its chiral recognition mechanism associated with drugs' structural features. Biomed Chromatogr. 2017 Nov;31(11). doi: 10.1002/bmc.3991. Epub 2017 May 28. PubMed PMID: 28431453. 4: Akiyama T, Miyahara H, Waki K, Yoshinaga H, Kobayashi K. A Japanese case of hereditary chin trembling responsive to arotinolol. Parkinsonism Relat Disord. 2016 Aug;29:133-4. doi: 10.1016/j.parkreldis.2016.04.021. Epub 2016 Apr 21. PubMed PMID: 27117562. 5: Lee DB, Woo YS, Bahk WM. Use of Arotinolol Pharmacotherapy to Treat Drug-induced Tremor: A Report of Three Cases. Pharmacopsychiatry. 2015 Jul;48(4-5):176-8. doi: 10.1055/s-0035-1549931. Epub 2015 May 13. PubMed PMID: 25970026. 6: Tang X, Hu X, Mei C, Yu S. Improvement of resistant hypertension by nocturnal hemodialysis in a patient with end-stage kidney disease. Case Rep Nephrol Dial. 2015 Feb 17;5(1):60-5. doi: 10.1159/000377671. eCollection 2015 Jan-Apr. PubMed PMID: 25874195; PubMed Central PMCID: PMC4376926. 7: Qian Z, Xu Y, Zheng L, Zhang J, Hong Z, Shen X. Enantiospecific determination of arotinolol in rat plasma by LC-MS/MS: application to a stereoselective pharmacokinetic study. J Pharm Biomed Anal. 2015 Jan;102:299-304. doi: 10.1016/j.jpba.2014.09.034. Epub 2014 Oct 2. PubMed PMID: 25459927. 8: Suzuki H. Pulse Pressure Is Useful for Determining the Choice of Antihypertensive Drugs in Postmenopausal Women. Pulse (Basel). 2014 May;1(3-4):152-60. doi: 10.1159/000360976. Epub 2014 Apr 11. PubMed PMID: 26587434; PubMed Central PMCID: PMC4315352. 9: Fang H, Chen W, Liu X, Xu W. The efficacy and safety of arotinolol combined with a different calcium channel blocker in the treatment of Chinese patients with essential hypertension: a one-year follow-up study. Clin Exp Hypertens. 2014;36(8):590-5. doi: 10.3109/10641963.2014.897714. Epub 2014 Mar 28. PubMed PMID: 24678807. 10: Zhou W, Hong M, Zhang K, Chen D, Han W, Shen W, Zhu D, Gao P. Mechanisms of improved aortic stiffness by arotinolol in spontaneously hypertensive rats. PLoS One. 2014 Feb 12;9(2):e88722. doi: 10.1371/journal.pone.0088722. eCollection 2014. PubMed PMID: 24533142; PubMed Central PMCID: PMC3923047. 11: Zappia M, Albanese A, Bruno E, Colosimo C, Filippini G, Martinelli P, Nicoletti A, Quattrocchi G, Abbruzzese G, Berardelli A, Allegra R, Aniello MS, Elia AE, Martino D, Murgia D, Picillo M, Squintani G. Treatment of essential tremor: a systematic review of evidence and recommendations from the Italian Movement Disorders Association. J Neurol. 2013 Mar;260(3):714-40. doi: 10.1007/s00415-012-6628-x. Epub 2012 Aug 11. Review. Erratum in: J Neurol. 2013 Mar;260(3):741. Abbruzzese, Giovanni [added]; Berardelli, Alfredo [added]; Allegra, Roberta [added]; Aniello, Maria Stella [added]; Elia, Antonio E [added]; Martino, Davide [added]; Murgia, Daniela [added]; Picillo, Marina [added]; Squintani, Giovanna [added]. PubMed PMID: 22886006. 12: Nakamura K, Fujio H. Are adrenergic receptor blockers effective or contraindicated in pulmonary arterial hypertension? Circ J. 2009 Dec;73(12):2212-3. PubMed PMID: 19940372. 13: Ishikawa M, Sato N, Asai K, Takano T, Mizuno K. Effects of a pure alpha/beta-adrenergic receptor blocker on monocrotaline-induced pulmonary arterial hypertension with right ventricular hypertrophy in rats. Circ J. 2009 Dec;73(12):2337-41. Epub 2009 Oct 13. PubMed PMID: 19822980. 14: Fan CM, Yang H, Li YS, Xu L, Dou KF, Zhao JL, Yuan XQ, Zhao YF, Shi RF, Du XQ, Lu NQ. Effect of arotinolol on left ventricular function in patients with idiopathic dilated cardiomyopathy. Chin Med Sci J. 2007 Dec;22(4):224-7. PubMed PMID: 18254186. 15: Mizuochi Y, Okajima K, Harada N, Molor-Erdene P, Uchiba M, Komura H, Tsuda T, Katsuya H. Carvedilol, a nonselective beta-blocker, suppresses the production of tumor necrosis factor and tissue factor by inhibiting early growth response factor-1 expression in human monocytes in vitro. Transl Res. 2007 Apr;149(4):223-30. PubMed PMID: 17383596. 16: Abdine H, Sultan MA, Hefnawy MM, Belal F. Spectrofluorometric determination of some beta-blockers in tablets and human plasma using 9,10-dimethoxyanthracene-2-sodium sulfonate. Pharmazie. 2005 Apr;60(4):265-8. PubMed PMID: 15881605. 17: Morita S, Miwa H, Kondo T. Effect of zonisamide on essential tremor: a pilot crossover study in comparison with arotinolol. Parkinsonism Relat Disord. 2005 Mar;11(2):101-3. PubMed PMID: 15734668. 18: Yamashita S, Maeda Y, Ohmori H, Uchida Y, Hirano T, Yonemura K, Uyama E, Uchino M. Pantothenate kinase-associated neurodegeneration initially presenting as postural tremor alone in a Japanese family with homozygous N245S substitutions in the pantothenate kinase gene. J Neurol Sci. 2004 Oct 15;225(1-2):129-33. PubMed PMID: 15465096. 19: Abe M, Mori K, Nagai K, Ito S. Relapse of Graves' disease in a patient with pheochromocytoma. Endocr J. 2003 Dec;50(6):767-70. PubMed PMID: 14709850. 20: Aboul-Enein HY, Hefnawy MM. Enantioselective determination of arotinolol in human plasma by HPLC using teicoplanin chiral stationary phase. Biomed Chromatogr. 2003 Oct;17(7):453-7. PubMed PMID: 14598329.