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MedKoo Cat#: 461866 | Name: Oxagrelate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Oxagrelate is a specific inhibitor of cyclic AMP phosphodiesterase, produced in vitro a concentration-dependent inhibition of platelet aggregation induced by collagen and ADP in human platelets.

Chemical Structure

Oxagrelate
Oxagrelate
CAS#56611-65-5

Theoretical Analysis

MedKoo Cat#: 461866

Name: Oxagrelate

CAS#: 56611-65-5

Chemical Formula: C14H16N2O4

Exact Mass: 276.1110

Molecular Weight: 276.29

Elemental Analysis: C, 60.86; H, 5.84; N, 10.14; O, 23.16

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Oxagrelate; EG 626; EG-626; EG626; Oxagrelato; Oxagrelatum; Phthalazinol; SC 32840; SC-32840; SC32840;
IUPAC/Chemical Name
ethyl 1-(hydroxymethyl)-5,7-dimethyl-4-oxo-3,4-dihydrophthalazine-6-carboxylate
InChi Key
DUQOOLBWGUKRAJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H16N2O4/c1-4-20-14(19)11-7(2)5-9-10(6-17)15-16-13(18)12(9)8(11)3/h5,17H,4,6H2,1-3H3,(H,16,18)
SMILES Code
O=C(C1=C(C)C2=C(C(CO)=NNC2=O)C=C1C)OCC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 276.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Azuma H, Takashima Y, Ishikawa M, Yamakado T. Potentiation of antiaggregating activity of adenosine by a phosphodiesterase inhibitor, EG626 (oxagrelate), in human platelets in vitro. Jpn J Pharmacol. 1984 Feb;34(2):159-70. PubMed PMID: 6205194. 2: Agarwal KC, Russo FX, Parks RE Jr. Inhibition of human and rat platelet aggregation by extracts of Mo-er (Auricularia auricula). Thromb Haemost. 1982 Oct 29;48(2):162-5. PubMed PMID: 6983740. 3: Panton RW, Agarwal KC, Robison BS, Parks RE Jr. Murine tumor-induced platelet aggregation and coagulation: mechanisms, inhibitors, and species differences. Thromb Res. 1987 Apr 1;46(1):65-76. PubMed PMID: 3590114. 4: Agarwal KC, Buckley RS, Parks RE Jr. Role of plasma adenosine in the antiplatelet action of HL 725, a potent inhibitor of cAMP phosphodiesterase: species differences. Thromb Res. 1987 Jul 15;47(2):191-200. PubMed PMID: 2821650.