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MedKoo Cat#: 128971 | Name: AB801

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AB801 is a novel, highly potent, selective, and orally bioavailable AXL inhibitor

Chemical Structure

AB801
AB801
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128971

Name: AB801

CAS#: N/A

Chemical Formula: C33H32N6O

Exact Mass: 528.2638

Molecular Weight: 528.66

Elemental Analysis: C, 74.98; H, 6.10; N, 15.90; O, 3.03

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
AB801; AB 801; AB-801
IUPAC/Chemical Name
6-((S)-2-(3-(3-methyl-[2,3'-bipyridin]-6'-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-7-yl)-3-oxa-6-azabicyclo[3.1.1]heptane
InChi Key
IANIKXYKEWAAKX-XWYKLZMASA-N
InChi Code
InChI=1S/C33H32N6O/c1-20-3-2-12-34-31(20)24-8-11-30(35-16-24)32-29-14-25(17-36-33(29)38-37-32)23-5-4-21-6-9-26(10-7-22(21)13-23)39-27-15-28(39)19-40-18-27/h2-5,8,11-14,16-17,26-28H,6-7,9-10,15,18-19H2,1H3,(H,36,37,38)/t26-,27?,28?/m0/s1
SMILES Code
CC(C=CC=N1)=C1C(C=N2)=CC=C2C3=NNC4=NC=C(C=C43)C5=CC=C(CC6)C(CC[C@H]6N7C8COCC7C8)=C5
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 528.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yang MC, Wang CC, Tang WC, Chen KM, Chen CY, Lin HH, Hsieh YC, Wang NH, Kuo YC, Chu PT, Tung HY, Wu YC, Sun JL, Liu SY, Li WF, Lee WH, Lai JS, Chang M, Lai MT. Immunogenicity of a spike protein subunit-based COVID-19 vaccine with broad protection against various SARS-CoV-2 variants in animal studies. PLoS One. 2023 Mar 24;18(3):e0283473. doi: 10.1371/journal.pone.0283473. PMID: 36961826; PMCID: PMC10038307. 2: Miles DH, Lamani M, Paladugu SR, Qu S, Foley CN, Sharif EU, Thomas J, Nareddy P, Beatty JW, Gal B, Zhao G, Grange R, Shaqfeh SG, Chen A, Singh H, Lee YT, Zhao X, Green D, Huang HT, Ginn E, Jin L, Paprcka SL, Fernández-Salas E, Zhou L, Johnson J, Adeojo L, Powers JP, Leleti MR. Discovery of AB801, a Potent and Selective Inhibitor of AXL Receptor Tyrosine Kinase for Use in Cancer Therapy. J Med Chem. 2025 May 23. doi: 10.1021/acs.jmedchem.5c00239. Epub ahead of print. PMID: 40407274. 3: Foley CN, Qu S, Paladugu SR, Lamani M, Grange R, Sharif EU, Thomas J, Nareddy P, Zhao G, Chen Y, Zhao X, Green D, Huang HT, Jin L, Paprcka SL, Fernandez-Salas E, Powers JP, Leleti MR, Miles DH. Discovery and Characterization of Potent, Selective, and Orally Bioavailable 7-Azaindazole AXL Receptor Tyrosine Kinase Inhibitors. J Med Chem. 2025 May 23. doi: 10.1021/acs.jmedchem.5c00238. Epub ahead of print. PMID: 40407249.