Nufenoxole | CAS#57726-65-5 | antidiarrhoeal agent

MedKoo Cat#: 461863 | Name: Nufenoxole

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Nufenoxole is an orally active antidiarrhoeal agent which binds to opioid receptors in the brain and myenteric plexus of the intestine.

Chemical Structure

Nufenoxole

CAS#57726-65-5

Theoretical Analysis

MedKoo Cat#: 461863

Name: Nufenoxole

CAS#: 57726-65-5

Chemical Formula: C25H29N3O

Exact Mass: 387.2311

Molecular Weight: 387.52

Elemental Analysis: C, 77.48; H, 7.54; N, 10.84; O, 4.13

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Nufenoxole; Nufenoxolum; SC 27166; SC-27166; SC27166;

IUPAC/Chemical Name

2-(3-(2-azabicyclo[2.2.2]octan-2-yl)-1,1-diphenylpropyl)-5-methyl-1,3,4-oxadiazole

InChi Key

CVOCKGAVXLCEGM-UHFFFAOYSA-N

InChi Code

InChI=1S/C25H29N3O/c1-19-26-27-24(29-19)25(21-8-4-2-5-9-21,22-10-6-3-7-11-22)16-17-28-18-20-12-14-23(28)15-13-20/h2-11,20,23H,12-18H2,1H3

SMILES Code

CC1=NN=C(C(C2=CC=CC=C2)(C3=CC=CC=C3)CCN4C(CC5)CCC5C4)O1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 387.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Brownsill RD, Hiley MP, Vose CW, Steiner JA, Stafford JE, McAllister A, Rose DA, Gerry N. Single- and multiple-dose pharmacokinetics of nufenoxole in healthy human subjects. Xenobiotica. 1987 Nov;17(11):1373-7. PubMed PMID: 3433806. 2: Moriarty KJ, Rolston DD, Kelly MJ, Shield M, Clark ML. Nufenoxole, a new antidiarrhoeal agent, inhibits fluid secretion in the human jejunum. Gut. 1985 Jan;26(1):75-80. PubMed PMID: 2578119; PubMed Central PMCID: PMC1432389. 3: Rachmilewitz D, Karmeli F. Effect of nufenoxole on human colonic prostanoid synthesis, Na-K-ATPase and adenylate cyclase activities. Eur J Pharmacol. 1984 Oct 30;106(1):153-8. PubMed PMID: 6152213. 4: Korey A, Zilm DH, Sellers EM. Dependence liability of two antidiarrheals, nufenoxole and loperamide. Clin Pharmacol Ther. 1980 May;27(5):659-64. PubMed PMID: 7371363. 5: Cook CS, Campion JG, Hribar JD, Karim A. Metabolism and pharmacokinetics of nufenoxole in animals and humans: an example of stereospecific hydroxylation of an isoquinuclidine ring. Xenobiotica. 1990 Oct;20(10):1065-80. PubMed PMID: 2082596. 6: Megens AA, Canters LL, Awouters FH, Niemegeers CJ. Is in vivo dissociation between the antipropulsive and antidiarrheal properties of opioids in rats related to gut selectivity? Arch Int Pharmacodyn Ther. 1989 Mar-Apr;298:220-9. PubMed PMID: 2569297.