BWA-6047 is a Dual AR/AR-V7 and GSPT1 Degrader. BWA-6047 exhibited potent protein degradation in 22Rv1 cells (AR: DC50 = 3.7 nM, Dmax = 90%; AR-V7: DC50 = 3.0 nM, Dmax = 93%; GSPT1: DC50 = 1.2 nM, Dmax = 94%). Mechanism experiments indicate that BWA-6047 functions as both PROTAC and molecular glue to degrade target proteins. Oral administration of BWA-6047 at 20 mpk significantly inhibited LNCaP xenograft tumor growth in mice without obvious toxicity.
MedKoo Cat#: 128898
Name: BWA-6047
CAS#: N/A
Chemical Formula: C42H46ClN5O7
Exact Mass: 767.3086
Molecular Weight: 768.31
Elemental Analysis: C, 65.66; H, 6.04; Cl, 4.61; N, 9.12; O, 14.58
The following data is based on the product molecular weight 768.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
