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MedKoo Cat#: 461855 | Name: Menbutone
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Menbutone is an oxobutyric acid derivative and acts as a choleretic.

Chemical Structure

Menbutone
Menbutone
CAS#3562-99-0

Theoretical Analysis

MedKoo Cat#: 461855

Name: Menbutone

CAS#: 3562-99-0

Chemical Formula: C15H14O4

Exact Mass: 258.0892

Molecular Weight: 258.27

Elemental Analysis: C, 69.76; H, 5.46; O, 24.78

Price and Availability

Size Price Availability Quantity
5g USD 250.00 2 weeks
10g USD 400.00 2 weeks
25g USD 750.00 2 Weeks
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Related CAS #
No Data
Synonym
Menbutone; Epanaftol; Fel-Bis; Genabil; Genabilin; Membutona; Menbutonum; Naftobil; SC 1749; SC-1749; SC1749; Sintobilina;
IUPAC/Chemical Name
4-(4-methoxynaphthalen-1-yl)-4-oxobutanoic acid
InChi Key
FHGJSJFIQNQBCK-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H14O4/c1-19-14-8-6-11(13(16)7-9-15(17)18)10-4-2-3-5-12(10)14/h2-6,8H,7,9H2,1H3,(H,17,18)
SMILES Code
O=C(O)CCC(C1=C2C=CC=CC2=C(OC)C=C1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Menbutone is an oxobutyric acid derivative, and is a choleretic.
In vitro activity:
Two novel series of TAC-fenbufen/menbutone conjugated molecules were designed, synthesized and bio-assayed. Five TAC-menbutone molecules showed improved AChE and Aβ aggregation inhibition capacity compared to TAC-fenbufen conjugated molecules. Overall, these novel series of molecules may be potential drug lead molecules in the treatment of AD. Reference: Chem Biodivers. 2021 Feb;18(2):e2000083. https://pubmed.ncbi.nlm.nih.gov/33448662/
In vivo activity:
Adult steers were given either clanobutin or menbutone intravenously and the effects on bile flow measured. When bile flow was previously reduced by reducing the total bile salts in the enterohepatic circulation both compounds were potent choleretics, increasing the volume of bile flow up to four-fold. Reference: Vet Rec. 1982 May 1;110(18):423-5. https://pubmed.ncbi.nlm.nih.gov/7090158/
Solvent mg/mL mM
Solubility
DMSO 45.5 176.17
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 258.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Hiremathad A, Chaves S, Keri RS. Multi-Targeting Tacrine Conjugates with Cholinesterase and Amyloid-Beta Inhibitory Activities: New Anti-Alzheimer's Agents. Chem Biodivers. 2021 Feb;18(2):e2000083. doi: 10.1002/cbdv.202000083. Epub 2021 Jan 15. PMID: 33448662. 2. Symonds HW. The choleretic effect of menbutone and clanobutin sodium in steers. Vet Rec. 1982 May 1;110(18):423-5. doi: 10.1136/vr.110.18.423. PMID: 7090158.
In vitro protocol:
Hiremathad A, Chaves S, Keri RS. Multi-Targeting Tacrine Conjugates with Cholinesterase and Amyloid-Beta Inhibitory Activities: New Anti-Alzheimer's Agents. Chem Biodivers. 2021 Feb;18(2):e2000083. doi: 10.1002/cbdv.202000083. Epub 2021 Jan 15. PMID: 33448662.
In vivo protocol:
Symonds HW. The choleretic effect of menbutone and clanobutin sodium in steers. Vet Rec. 1982 May 1;110(18):423-5. doi: 10.1136/vr.110.18.423. PMID: 7090158.
1: Symonds HW. The choleretic effect of menbutone and clanobutin sodium in steers. Vet Rec. 1982 May 1;110(18):423-5. PubMed PMID: 7090158. 2: Lund J, Lassen JB. Elimination and distribution of menbutone (Genabil) in rats. Acta Pharmacol Toxicol (Copenh). 1969;27(6):429-38. PubMed PMID: 5395732.