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MedKoo Cat#: 465367 | Name: SR-1114

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SR-1114 is a first-in-class ENL PROTAC.

Chemical Structure

SR-1114
SR-1114
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465367

Name: SR-1114

CAS#: unknown

Chemical Formula: C41H47N9O11S

Exact Mass: 873.3116

Molecular Weight: 873.94

Elemental Analysis: C, 56.35; H, 5.42; N, 14.42; O, 20.14; S, 3.67

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
SR-1114; GTPL11542; HY-115881; CS-0374044
IUPAC/Chemical Name
N-cyclobutyl-2-(3-((N-(14-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-13-oxo-6,9-dioxa-3,12-diazatetradecyl)sulfamoyl)amino)phenyl)imidazo[1,2-a]pyridine-6-carboxamide
InChi Key
SAWYHUROXWLIIW-UHFFFAOYSA-N
InChi Code
InChI=1S/C41H47N9O11S/c51-35-13-11-32(39(54)47-35)50-40(55)30-8-3-9-33(37(30)41(50)56)61-25-36(52)43-17-19-60-21-20-59-18-16-42-14-15-44-62(57,58)48-29-7-1-4-26(22-29)31-24-49-23-27(10-12-34(49)46-31)38(53)45-28-5-2-6-28/h1,3-4,7-10,12,22-24,28,32,42,44,48H,2,5-6,11,13-21,25H2,(H,43,52)(H,45,53)(H,47,51,54)
SMILES Code
O=C(C1=CN2C(C=C1)=NC(C3=CC=CC(NS(=O)(NCCNCCOCCOCCNC(COC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O)=O)=O)=C3)=C2)NC7CCC7
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 873.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Garnar-Wortzel L, Bishop TR, Kitamura S, Milosevich N, Asiaban JN, Zhang X, Zheng Q, Chen E, Ramos AR, Ackerman CJ, Hampton EN, Chatterjee AK, Young TS, Hull MV, Sharpless KB, Cravatt BF, Wolan DW, Erb MA. Chemical Inhibition of ENL/AF9 YEATS Domains in Acute Leukemia. ACS Cent Sci. 2021 May 26;7(5):815-830. doi: 10.1021/acscentsci.0c01550. Epub 2021 Apr 30. PMID: 34079898; PMCID: PMC8161486.