IUPAC/Chemical Name
L-Arginine mono(2-mercaptoethanesulfonate)
InChi Key
MZDDDSNBRVMDIH-WCCKRBBISA-N
InChi Code
InChI=1S/C6H14N4O2.C2H6O3S2/c7-4(5(11)12)2-1-3-10-6(8)9;3-7(4,5)2-1-6/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);6H,1-2H2,(H,3,4,5)/t4-;/m0./s1
SMILES Code
N[C@@H](CCCNC(N)=N)C(O)=O.SCCS(=O)(O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
316.39
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Cargnoni A, Comini L, Boraso A, De Giuli F, Scotti C, Ferrari R. The effects of L-arginine mono(2-mercaptoethanesulfonate) on the ischemic and reperfused heart. Cardioscience. 1992 Sep;3(3):179-87. PubMed PMID: 1420954.
2: Frustaci S, Foladore S, De Pascale A, Freschi A, Lo Re G, Sorio R, Errante D, Monfardini S. Feasibility and efficacy of arginine 2-mercaptoethanesulfonate (ARGIMESNA) in the prevention of hemorragic cystitis from ifosfamide (IFO). Ann Oncol. 1992 Apr;3 Suppl 2:S115-8. PubMed PMID: 1622852.
3: Pea F, Mazzo M, Miglioli PA, Casiglia E, Pessina A, Moretti V. Serum concentrations of sodium 2-mercaptoethanesulfonate (MESNA) and its metabolite, disulfide form (DIMESNA), in volunteers after oral dosing: a comparison between MESNA and ARGIMESNA. Pharmacol Res. 1992 Feb-Mar;25 Suppl 1:85-6. PubMed PMID: 1508821.
4: Magnolfi Zipoli G, D'Ancona S, Berti T. Arginine 2-mercaptoethane sulfonate and sodium 2-mercaptoethane sulfonate: a comparative study of their effects upon tumour cells. Drugs Exp Clin Res. 1988;14(7):473-8. PubMed PMID: 3149236.
