MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 592938 | Name: Trimethaphan camsylate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Trimethaphan is a nicotinic antagonist that has been used as a ganglionic blocker in hypertension.

Chemical Structure

Trimethaphan camsylate
Trimethaphan camsylate
CAS#68-91-7 (camsylate)

Theoretical Analysis

MedKoo Cat#: 592938

Name: Trimethaphan camsylate

CAS#: 68-91-7 (camsylate)

Chemical Formula: C32H40N2O5S2

Exact Mass: 596.2379

Molecular Weight: 596.80

Elemental Analysis: C, 64.40; H, 6.76; N, 4.69; O, 13.40; S, 10.74

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
7187-66-8 (cation) 7728-39-4 (cation) 68-91-7 (camsylate) 520-38-7 (hydroxide) 52028-34-9 (chloride)
Synonym
Trimethaphan camsylate
IUPAC/Chemical Name
Decahydro-2-oxo-1,3-bis(phenylmethyl)thieno(1',2':1,2) thieno(3,4-d)imidazol-5-ium, salt with (1S)-7,7-dimethyl-2-oxobicyclo(2.2.1)heptane-1-methanesulfon ic acid (1:1)
InChi Key
HALWUDBBYKMYPW-STOWLHSFSA-M
InChi Code
InChI=1S/C22H25N2OS.C10H16O4S/c25-22-23(14-17-8-3-1-4-9-17)19-16-26-13-7-12-20(26)21(19)24(22)15-18-10-5-2-6-11-18;1-9(2)7-3-4-10(9,8(11)5-7)6-15(12,13)14/h1-6,8-11,19-21H,7,12-16H2;7H,3-6H2,1-2H3,(H,12,13,14)/q+1;/p-1/t;7-,10-/m.1/s1
SMILES Code
CC1([C@@H]2CC[C@]1(C(C2)=O)CS(=O)([O-])=O)C.O=C3N(C4C[S+]5CCCC5C4N3Cc6ccccc6)Cc7ccccc7
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 596.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Klassen SA, Limberg JK, Baker SE, Nicholson WT, Curry TB, Joyner MJ, Shoemaker JK. The role of the paravertebral ganglia in human sympathetic neural discharge patterns. J Physiol. 2018 Jul 28. doi: 10.1113/JP276440. [Epub ahead of print] PubMed PMID: 30054928. 2: Peinado AB, Harvey RE, Hart EC, Charkoudian N, Curry TB, Nicholson WT, Wallin BG, Joyner MJ, Barnes JN. Neural control of blood pressure in women: differences according to age. Clin Auton Res. 2017 Jun;27(3):157-165. doi: 10.1007/s10286-017-0403-0. Epub 2017 Feb 16. PubMed PMID: 28205011; PubMed Central PMCID: PMC5604236. 3: Harvey RE, Barnes JN, Hart EC, Nicholson WT, Joyner MJ, Casey DP. Influence of sympathetic nerve activity on aortic hemodynamics and pulse wave velocity in women. Am J Physiol Heart Circ Physiol. 2017 Feb 1;312(2):H340-H346. doi: 10.1152/ajpheart.00447.2016. Epub 2016 Dec 6. PubMed PMID: 27923789; PubMed Central PMCID: PMC5336574. 4: Barnes JN, Hart EC, Curry TB, Nicholson WT, Eisenach JH, Wallin BG, Charkoudian N, Joyner MJ. Aging enhances autonomic support of blood pressure in women. Hypertension. 2014 Feb;63(2):303-8. doi: 10.1161/HYPERTENSIONAHA.113.02393. Epub 2013 Dec 9. PubMed PMID: 24324040; PubMed Central PMCID: PMC3893094. 5: Wang R, Foniok T, Wamsteeker JI, Qiao M, Tomanek B, Vivanco RA, Tuor UI. Transient blood pressure changes affect the functional magnetic resonance imaging detection of cerebral activation. Neuroimage. 2006 May 15;31(1):1-11. Epub 2006 Feb 3. PubMed PMID: 16460967. 6: Alipov NN, Sokolov AV, Trubetskaya LV, Kuznetsova TE. Whether independent regulation of myocardial contractility and diastolic relaxation rate is possible? Bull Exp Biol Med. 2003 Apr;135(4):330-3. PubMed PMID: 12910300. 7: Alipov NN, Sokolov AV, Trubetskaya LV, Kuznetsova TE. Contraction and relaxation indices in the study of neural inotropic and loositropic influences on the heart. Bull Exp Biol Med. 2001 Dec;132(6):1141-4. PubMed PMID: 12152869. 8: El-Omar M, Kardos A, Casadei B. Mechanisms of respiratory sinus arrhythmia in patients with mild heart failure. Am J Physiol Heart Circ Physiol. 2001 Jan;280(1):H125-31. PubMed PMID: 11123226. 9: Varon J, Marik PE. The diagnosis and management of hypertensive crises. Chest. 2000 Jul;118(1):214-27. Review. PubMed PMID: 10893382. 10: Kuroda K, Kuwata N, Sato N, Funayama M, Yabuta A, Taguchi S, Suzuki M, Takahashi A, Ogawa A. Changes in cerebral blood flow accompanied with reduction of blood pressure treatment in patients with hypertensive intracerebral hemorrhages. Neurol Res. 1997 Apr;19(2):169-73. PubMed PMID: 9175147. 11: Forsyth CS, Speth RC, Wecker L, Galey FD, Frank AA. Comparison of nicotinic receptor binding and biotransformation of coniine in the rat and chick. Toxicol Lett. 1996 Dec 31;89(3):175-83. PubMed PMID: 9001585. 12: Newton MC, Chadd GD, O'Donoghue B, Sapsed-Byrne SM, Hall GM. Metabolic and hormonal responses to induced hypotension for middle ear surgery. Br J Anaesth. 1996 Mar;76(3):352-7. PubMed PMID: 8785132. 13: Petrides G, Maneksha F, Zervas I, Carasiti I, Francis A. Trimethaphan (Arfonad) control of hypertension and tachycardia during electroconvulsive therapy: a double-blind study. J Clin Anesth. 1996 Mar;8(2):104-9. PubMed PMID: 8695090. 14: Hammer GB. Ultra-high dose trimethaphan in an infant with severe hypertension. J Toxicol Clin Toxicol. 1996;34(2):227-9. PubMed PMID: 8618259. 15: Thompson BG, Pluta RM, Girton ME, Oldfield EH. Nitric oxide mediation of chemoregulation but not autoregulation of cerebral blood flow in primates. J Neurosurg. 1996 Jan;84(1):71-8. PubMed PMID: 8613839. 16: Khadra MH, Satchell PM, Vaughan CW. Sympathetic nervous system effects on feline bladder wall compliance throughout continence. Acta Physiol Scand. 1995 Sep;155(1):31-9. PubMed PMID: 8553875. 17: Wotring VE, Yoon KW. The inhibitory effects of nicotinic antagonists on currents elicited by GABA in rat hippocampal neurons. Neuroscience. 1995 Jul;67(2):293-300. PubMed PMID: 7675170. 18: Akopian VP, Kocharian AZh, Topchian AV, Mirzoian NR. [The cerebral blood circulation during hypokinesia under the influence of hypercapnia, hypotonia, GABA and neurosensory stimulation]. Eksp Klin Farmakol. 1995 Jul-Aug;58(4):23-5. Russian. PubMed PMID: 7580746. 19: Erostegui C, Norris CH, Bobbin RP. In vitro pharmacologic characterization of a cholinergic receptor on outer hair cells. Hear Res. 1994 Apr;74(1-2):135-47. PubMed PMID: 8040084. 20: Moursi MM, Facktor MA, Zelenock GB, D'Alecy LG. Systemic hypertension induced by aortic cross-clamping: detrimental effects of direct smooth muscle relaxation compared with ganglionic blockade. J Vasc Surg. 1994 Apr;19(4):707-16. PubMed PMID: 7909338.