MedKoo Cat#: 592935 | Name: Arabinofuranosyluracil
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Arabinofuranosyluracil is a pyrimidine nucleoside formed in the body by the deamination of CYTARABINE.

Chemical Structure

Arabinofuranosyluracil
CAS# 3083-77-0

Theoretical Analysis

MedKoo Cat#: 592935

Name: Arabinofuranosyluracil

CAS#: 3083-77-0

Chemical Formula: C9H12N2O6

Exact Mass: 244.0695

Molecular Weight: 244.20

Elemental Analysis: C, 44.27; H, 4.95; N, 11.47; O, 39.31

Price and Availability

Size Price Availability Quantity
5g USD 250.00 2 Weeks
10g USD 350.00 2 Weeks
25g USD 650.00 2 Weeks
100g USD 1,450.00 2 Weeks
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Related CAS #
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Synonym
Arabinofuranosyluracil; Ara-U; Arabinosyluracil; Arauridine; NSC 68928; NSC68928; NSC-68928; Spongouridin; Uracil arabinoside; Uracil-beta-D-arabinofuranoside; Uridine arabinoside;
IUPAC/Chemical Name
1-beta-D-Arabinofuranosyl-(1H,3H)-pyrimidine-2,4-dione
InChi Key
DRTQHJPVMGBUCF-CCXZUQQUSA-N
InChi Code
InChI=1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7+,8-/m1/s1
SMILES Code
O=C1NC(C=CN1[C@H]2[C@H]([C@@H]([C@@H](CO)O2)O)O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 244.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Varghese B, Velez E, Desai B, Jadvar H. Incidental Detection of Meningioma by 18F-FMAU PET/CT in a Patient With Suspected Prostate Cancer. Clin Nucl Med. 2018 Jul;43(7):e245-e246. doi: 10.1097/RLU.0000000000002123. PubMed PMID: 29742600; PubMed Central PMCID: PMC5980759. 2: Alauddin MM. Journey of 2'-deoxy-2'-fluoro-5-methyl-1-β-D-arabinofuranosyluracil (FMAU): from Antiviral Drug to PET Imaging Agent. Curr Med Chem. 2018;25(16):1867-1878. doi: 10.2174/0929867325666171129125217. PubMed PMID: 29189119. 3: Park SH, Park KS, Kim NH, Cho JY, Koh MS, Lee JH. Clevudine Induced Mitochondrial Myopathy. J Korean Med Sci. 2017 Nov;32(11):1857-1860. doi: 10.3346/jkms.2017.32.11.1857. PubMed PMID: 28960041; PubMed Central PMCID: PMC5639069. 4: He L, Liu X, Zhao Y, Zhang S, Jiang Y, Wang X, Yang Z. Efficacy of Nucleot(s)ide Analogs Therapy in Patients with Unresectable HBV-Related Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis. Dis Markers. 2017;2017:7075935. doi: 10.1155/2017/7075935. Epub 2017 Mar 15. Review. PubMed PMID: 28396612; PubMed Central PMCID: PMC5370486. 5: Vaishampayan UN, Tehrani OS, Lawhorn-Crews JM, Heilbrun LK, Dobson K, Smith D, Dickow B, Shields AF. A Pilot Trial Evaluating Zoledronic Acid Induced Changes in [(18)F]FMAU-Positron Emission Tomography Imaging of Bone Metastases in Prostate Cancer. Mol Imaging Biol. 2017 Dec;19(6):810-816. doi: 10.1007/s11307-017-1057-y. PubMed PMID: 28289967. 6: Jadvar H, Park R, Yap LP, Chen K, Hughes L, Conti P. Effect of Androgen on Normal Biodistribution of [(18)F]-2'-Fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (18F-FMAU) in Athymic Non-tumor-bearing Male Mice. Anticancer Res. 2017 Feb;37(2):475-479. PubMed PMID: 28179292; PubMed Central PMCID: PMC5404414. 7: Najjar AM, Manuri PR, Olivares S, Flores L 2nd, Mi T, Huls H, Shpall EJ, Champlin RE, Turkman N, Paolillo V, Roszik J, Rabinovich B, Lee DA, Alauddin M, Gelovani J, Cooper LJ. Imaging of Sleeping Beauty-Modified CD19-Specific T Cells Expressing HSV1-Thymidine Kinase by Positron Emission Tomography. Mol Imaging Biol. 2016 Dec;18(6):838-848. PubMed PMID: 27246312; PubMed Central PMCID: PMC5096958. 8: McHugh CI, Lawhorn-Crews JM, Modi D, Douglas KA, Jones SK, Mangner TJ, Collins JM, Shields AF. Effects of capecitabine treatment on the uptake of thymidine analogs using exploratory PET imaging agents: (18)F-FAU, (18)F-FMAU, and (18)F-FLT. Cancer Imaging. 2016 Oct 17;16(1):34. PubMed PMID: 27751167; PubMed Central PMCID: PMC5067904. 9: Jadvar H. PET of Glucose Metabolism and Cellular Proliferation in Prostate Cancer. J Nucl Med. 2016 Oct;57(Suppl 3):25S-29S. Review. PubMed PMID: 27694167; PubMed Central PMCID: PMC5093915. 10: Cho EY, Yim HJ, Jung YK, Suh SJ, Seo YS, Kim JH, Kim HS, Lee SH, Ahn SH, Lee JI, Jeong SH, Kim JW, Lee JW, Kim IH, Kim HS, Park SJ, Lee JM, Hwang SG; Antiviral Resistance Study Group. Management of Clevudine-Resistant Chronic Hepatitis B: A Multicenter Cohort Study. Gut Liver. 2017 Jan 15;11(1):129-135. doi: 10.5009/gnl15597. PubMed PMID: 27538443; PubMed Central PMCID: PMC5221870. 11: Jadvar H. Imaging Cellular Proliferation in Prostate Cancer with Positron Emission Tomography. Asia Ocean J Nucl Med Biol. 2015 Summer;3(2):72-6. Review. PubMed PMID: 27408885; PubMed Central PMCID: PMC4937643. 12: Zhang XM, Zhang HH, McLeroth P, Berkowitz RD, Mont MA, Stabin MG, Siegel BA, Alavi A, Barnett TM, Gelb J, Petit C, Spaltro J, Cho SY, Pomper MG, Conklin JJ, Bettegowda C, Saha S. [(124)I]FIAU: Human dosimetry and infection imaging in patients with suspected prosthetic joint infection. Nucl Med Biol. 2016 May;43(5):273-9. doi: 10.1016/j.nucmedbio.2016.01.004. Epub 2016 Feb 2. PubMed PMID: 27150029. 13: Bell CC, Hendriks DF, Moro SM, Ellis E, Walsh J, Renblom A, Fredriksson Puigvert L, Dankers AC, Jacobs F, Snoeys J, Sison-Young RL, Jenkins RE, Nordling Å, Mkrtchian S, Park BK, Kitteringham NR, Goldring CE, Lauschke VM, Ingelman-Sundberg M. Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease. Sci Rep. 2016 May 4;6:25187. doi: 10.1038/srep25187. PubMed PMID: 27143246; PubMed Central PMCID: PMC4855186. 14: Li J, Kim S, Shields AF, Douglas KA, McHugh CI, Lawhorn-Crews JM, Wu J, Mangner TJ, LoRusso PM. Integrating Dynamic Positron Emission Tomography and Conventional Pharmacokinetic Studies to Delineate Plasma and Tumor Pharmacokinetics of FAU, a Prodrug Bioactivated by Thymidylate Synthase. J Clin Pharmacol. 2016 Nov;56(11):1433-1447. doi: 10.1002/jcph.751. PubMed PMID: 27095537; PubMed Central PMCID: PMC5584379. 15: Wang D, Xiao Q, Yang W, Qian W, Yang J. HPLC-MS/MS method for the simultaneous determination of MB07133 and its metabolites, cytarabine and arabinofuranosyluracil, in rat plasma. J Pharm Biomed Anal. 2016 Feb 20;120:228-34. doi: 10.1016/j.jpba.2015.12.049. Epub 2015 Dec 29. PubMed PMID: 26760240. 16: Yang FY, Chang WY, Lin WT, Hwang JJ, Chien YC, Wang HE, Tsai ML. Focused ultrasound enhanced molecular imaging and gene therapy for multifusion reporter gene in glioma-bearing rat model. Oncotarget. 2015 Nov 3;6(34):36260-8. doi: 10.18632/oncotarget.5389. PubMed PMID: 26429860; PubMed Central PMCID: PMC4742175. 17: Hyo Kim L, Sub Cheong H, Koh Y, Ahn KS, Lee C, Kim HL, Doo Shin H, Yoon SS. Cytidine deaminase polymorphisms and worse treatment response in normal karyotype AML. J Hum Genet. 2015 Dec;60(12):749-54. doi: 10.1038/jhg.2015.105. Epub 2015 Sep 10. PubMed PMID: 26354033. 18: Bombardieri E, Setti L, Kirienko M, Antunovic L, Guglielmo P, Ciocia G. Which metabolic imaging, besides bone scan with 99mTc-phosphonates, for detecting and evaluating bone metastases in prostatic cancer patients? An open discussion. Q J Nucl Med Mol Imaging. 2015 Dec;59(4):381-99. Epub 2015 Sep 3. Review. PubMed PMID: 26337240. 19: Ahn SH, Kim DH, Lee AR, Kim BK, Park YK, Park ES, Ahn SH, Shin GC, Park S, Kang HS, Rhee JK, Yang SI, Chong Y, Kim KH. Substitution at rt269 in Hepatitis B Virus Polymerase Is a Compensatory Mutation Associated with Multi-Drug Resistance. PLoS One. 2015 Aug 31;10(8):e0136728. doi: 10.1371/journal.pone.0136728. eCollection 2015. PubMed PMID: 26322642; PubMed Central PMCID: PMC4556173. 20: Moroz MA, Zhang H, Lee J, Moroz E, Zurita J, Shenker L, Serganova I, Blasberg R, Ponomarev V. Comparative Analysis of T Cell Imaging with Human Nuclear Reporter Genes. J Nucl Med. 2015 Jul;56(7):1055-60. doi: 10.2967/jnumed.115.159855. Epub 2015 May 29. PubMed PMID: 26025962; PubMed Central PMCID: PMC4511596.