MedKoo Cat#: 461813 | Name: Sargachromanol E

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sargachromanol E is a compound isolated from the marine brown alga, Sargassum horneri. It has been studied for its inhibitory effect on skin ageing.

Chemical Structure

Sargachromanol E
Sargachromanol E
CAS#856414-54-5

Theoretical Analysis

MedKoo Cat#: 461813

Name: Sargachromanol E

CAS#: 856414-54-5

Chemical Formula: C27H40O4

Exact Mass: 428.2927

Molecular Weight: 428.61

Elemental Analysis: C, 75.66; H, 9.41; O, 14.93

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Sargachromanol E; Sargachromanol-E;
IUPAC/Chemical Name
(4S,5S,6E,10E)-13-((R)-6-hydroxy-2,8-dimethylchroman-2-yl)-2,6,10-trimethyltrideca-2,6,10-triene-4,5-diol
InChi Key
YIWOAJFKIIOXPS-BXYCSXDPSA-N
InChi Code
InChI=1S/C27H40O4/c1-18(2)15-24(29)25(30)20(4)11-7-9-19(3)10-8-13-27(6)14-12-22-17-23(28)16-21(5)26(22)31-27/h10-11,15-17,24-25,28-30H,7-9,12-14H2,1-6H3/b19-10+,20-11+/t24-,25-,27+/m0/s1
SMILES Code
C/C(C)=C\[C@H](O)[C@@H](O)/C(C)=C/CC/C(C)=C/CC[C@]1(C)CCC2=CC(O)=CC(C)=C2O1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 428.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lee JH, Ko JY, Samarakoon K, Oh JY, Heo SJ, Kim CY, Nah JW, Jang MK, Lee JS, Jeon YJ. Preparative isolation of sargachromanol E from Sargassum siliquastrum by centrifugal partition chromatography and its anti-inflammatory activity. Food Chem Toxicol. 2013 Dec;62:54-60. doi: 10.1016/j.fct.2013.08.010. Epub 2013 Aug 20. PubMed PMID: 23973192. 2: Kim JA, Ahn BN, Kong CS, Kim SK. The chromene sargachromanol E inhibits ultraviolet A-induced ageing of skin in human dermal fibroblasts. Br J Dermatol. 2013 May;168(5):968-76. doi: 10.1111/bjd.12187. Epub 2013 Apr 2. PubMed PMID: 23278330. 3: Heo SJ, Kim KN, Yoon WJ, Oh C, Choi YU, Affan A, Lee YJ, Lee HS, Kang DH. Chromene induces apoptosis via caspase-3 activation in human leukemia HL-60 cells. Food Chem Toxicol. 2011 Sep;49(9):1998-2004. doi: 10.1016/j.fct.2011.05.011. Epub 2011 May 11. PubMed PMID: 21600262.