Dolutegravir Sodium | CAS#1051375-19-9 | integrase inhibitor

MedKoo Cat#: 563693 | Name: Dolutegravir Sodium

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dolutegravir, also known as GSK1349572, is a potent inhibitor of HIV integrase with an IC50 value of 2.7 nM for HIV-1 integrase-catalyzed strand transfer in vitro.1 It inhibits HIV-1 viral replication (EC50 = 0.51 nM) in peripheral blood mononuclear cells (PBMCs). Dolutegravir (DTG) is an antiretroviral medication used, together with other medication, to treat HIV/AIDS. It may also be used, as part of post exposure prophylaxis, to prevent HIV infection following potential exposure.

Chemical Structure

Dolutegravir Sodium

CAS#1051375-19-9 (sodium)

Theoretical Analysis

MedKoo Cat#: 563693

Name: Dolutegravir Sodium

CAS#: 1051375-19-9 (sodium)

Chemical Formula: C20H18F2N3NaO5

Exact Mass: 441.1112

Molecular Weight: 441.36

Elemental Analysis: C, 54.43; H, 4.11; F, 8.61; N, 9.52; Na, 5.21; O, 18.12

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

1051375-19-9 (sodium) 1051375-16-6 (free) 1357289-29-2 (RR-isomer) 1309560-49-3 (SR isomer)

Synonym

Dolutegravir Sodium; GSK-1349572; GSK1349572; GSK 1349572;

IUPAC/Chemical Name

(4R,12aS)-N-(2,4-Difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide Sodium salt

InChi Key

VMYYLTRYLSNWCA-VSLILLSYSA-M

InChi Code

InChI=1S/C20H19F2N3O5.Na/c1-10-4-5-30-15-9-24-8-13(17(26)18(27)16(24)20(29)25(10)15)19(28)23-7-11-2-3-12(21)6-14(11)22;/h2-3,6,8,10,15H,4-5,7,9H2,1H3,(H2,23,27,28,29);/q;+1/p-1/t10-,15+;/m1./s1

SMILES Code

O=C(C1=CN(C2=C(O)C1=O)C[C@]3([H])OCC[C@@H](C)N3C2=O)[N-]CC4=CC=C(F)C=C4F.[Na+]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 441.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.