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MedKoo Cat#: 592834 | Name: Amolanone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Amolanone is a Local Anesthetic.

Chemical Structure

Amolanone
Amolanone
CAS#76-65-3

Theoretical Analysis

MedKoo Cat#: 592834

Name: Amolanone

CAS#: 76-65-3

Chemical Formula: C20H23NO2

Exact Mass: 309.1729

Molecular Weight: 309.41

Elemental Analysis: C, 77.64; H, 7.49; N, 4.53; O, 10.34

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Amolanone; AP 43; AP-43; AP43
IUPAC/Chemical Name
2(3H)-Benzofuranone, 3-(beta-diethylaminoethyl)-3-phenyl-
InChi Key
HPITVGRITATAFY-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H23NO2/c1-3-21(4-2)15-14-20(16-10-6-5-7-11-16)17-12-8-9-13-18(17)23-19(20)22/h5-13H,3-4,14-15H2,1-2H3
SMILES Code
O=C1OC2=CC=CC=C2C1(CCN(CC)CC)C3=CC=CC=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 309.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hjuler CT, Maolanon NN, Sauer J, Stougaard J, Thygesen MB, Jensen KJ. Preparation of glycoconjugates from unprotected carbohydrates for protein-binding studies. Nat Protoc. 2017 Nov;12(11):2411-2422. doi: 10.1038/nprot.2017.109. Epub 2017 Oct 26. PubMed PMID: 29072708. 2: Kitir B, Maolanon AR, Ohm RG, Colaço AR, Fristrup P, Madsen AS, Olsen CA. Chemical Editing of Macrocyclic Natural Products and Kinetic Profiling Reveal Slow, Tight-Binding Histone Deacetylase Inhibitors with Picomolar Affinities. Biochemistry. 2017 Sep 26;56(38):5134-5146. doi: 10.1021/acs.biochem.7b00725. Epub 2017 Sep 15. PubMed PMID: 28858522. 3: Maolanon AR, Risgaard R, Wang SY, Snoep Y, Papangelis A, Yi F, Holley D, Barslund AF, Svenstrup N, Hansen KB, Clausen RP. Subtype-Specific Agonists for NMDA Receptor Glycine Binding Sites. ACS Chem Neurosci. 2017 Aug 16;8(8):1681-1687. doi: 10.1021/acschemneuro.7b00117. Epub 2017 May 30. PubMed PMID: 28514141; PubMed Central PMCID: PMC5559341. 4: Maolanon AR, Kristensen HM, Leman LJ, Ghadiri MR, Olsen CA. Natural and Synthetic Macrocyclic Inhibitors of the Histone Deacetylase Enzymes. Chembiochem. 2017 Jan 3;18(1):5-49. doi: 10.1002/cbic.201600519. Epub 2016 Dec 8. Review. PubMed PMID: 27748555. 5: Maolanon AR, Madsen AS, Olsen CA. Innovative Strategies for Selective Inhibition of Histone Deacetylases. Cell Chem Biol. 2016 Jul 21;23(7):759-768. doi: 10.1016/j.chembiol.2016.06.011. Review. PubMed PMID: 27447046. 6: Maolanon AR, Villadsen JS, Christensen NJ, Hoeck C, Friis T, Harris P, Gotfredsen CH, Fristrup P, Olsen CA. Methyl effect in azumamides provides insight into histone deacetylase inhibition by macrocycles. J Med Chem. 2014 Nov 26;57(22):9644-57. doi: 10.1021/jm501399d. Epub 2014 Nov 7. PubMed PMID: 25380299. 7: Sørensen KK, Simonsen JB, Maolanon NN, Stougaard J, Jensen KJ. Chemically synthesized 58-mer LysM domain binds lipochitin oligosaccharide. Chembiochem. 2014 Sep 22;15(14):2097-105. doi: 10.1002/cbic.201402125. Epub 2014 Aug 26. PubMed PMID: 25154732. 8: Maolanon NN, Blaise M, Sørensen KK, Thygesen MB, Cló E, Sullivan JT, Ronson CW, Stougaard J, Blixt O, Jensen KJ. Lipochitin oligosaccharides immobilized through oximes in glycan microarrays bind LysM proteins. Chembiochem. 2014 Feb 10;15(3):425-34. doi: 10.1002/cbic.201300520. Epub 2014 Jan 16. PubMed PMID: 24436194. 9: Villadsen JS, Stephansen HM, Maolanon AR, Harris P, Olsen CA. Total synthesis and full histone deacetylase inhibitory profiling of Azumamides A-E as well as β²- epi-Azumamide E and β³-epi-Azumamide E. J Med Chem. 2013 Aug 22;56(16):6512-20. doi: 10.1021/jm4008449. Epub 2013 Aug 5. Erratum in: J Med Chem. 2013 Sep 12;56(17):7135. PubMed PMID: 23865683. 10: Broghammer A, Krusell L, Blaise M, Sauer J, Sullivan JT, Maolanon N, Vinther M, Lorentzen A, Madsen EB, Jensen KJ, Roepstorff P, Thirup S, Ronson CW, Thygesen MB, Stougaard J. Legume receptors perceive the rhizobial lipochitin oligosaccharide signal molecules by direct binding. Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13859-64. doi: 10.1073/pnas.1205171109. Epub 2012 Aug 2. PubMed PMID: 22859506; PubMed Central PMCID: PMC3427107. 11: Frandsen RJ, Nielsen NJ, Maolanon N, Sørensen JC, Olsson S, Nielsen J, Giese H. The biosynthetic pathway for aurofusarin in Fusarium graminearum reveals a close link between the naphthoquinones and naphthopyrones. Mol Microbiol. 2006 Aug;61(4):1069-80. PubMed PMID: 16879655.