Caylin-2 | CAS#1392830-09-9 | Mdm2 inhibitor

MedKoo Cat#: 563679 | Name: Caylin-2

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Caylin-2 is a Mdm2 inhibitor, an analog of Nutlin-3.

Chemical Structure

Caylin-2

CAS#1392830-09-9

Theoretical Analysis

MedKoo Cat#: 563679

Name: Caylin-2

CAS#: 1392830-09-9

Chemical Formula: C32H30F6N4O4

Exact Mass: 648.2171

Molecular Weight: 648.60

Elemental Analysis: C, 59.26; H, 4.66; F, 17.57; N, 8.64; O, 9.87

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Caylin-2; Caylin 2; Caylin2;

IUPAC/Chemical Name

rel-4-[[(4R,5S)-4,5-Bis(4-(trifluoromethyl)phenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone

InChi Key

HXLGOAAYXPLLCI-IZLXSDGUSA-N

InChi Code

InChI=1S/C32H30F6N4O4/c1-18(2)46-25-16-23(45-3)12-13-24(25)29-40-27(19-4-8-21(9-5-19)31(33,34)35)28(20-6-10-22(11-7-20)32(36,37)38)42(29)30(44)41-15-14-39-26(43)17-41/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,39,43)/t27-,28+/m1/s1

SMILES Code

O=C1NCCN(C(N2[C@@H](C3=CC=C(C(F)(F)F)C=C3)[C@@H](C4=CC=C(C(F)(F)F)C=C4)N=C2C5=CC=C(OC)C=C5OC(C)C)=O)C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 648.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Verma R, Rigatti MJ, Belinsky GS, Godman CA, Giardina C. DNA damage response to the Mdm2 inhibitor nutlin-3. Biochem Pharmacol. 2010 Feb 15;79(4):565-74. doi: 10.1016/j.bcp.2009.09.020. PubMed PMID: 19788889; PubMed Central PMCID: PMC2794967.