Synonym
MD 780236; MD780236; MD-780236;
IUPAC/Chemical Name
2-Oxazolidinone, 3-(4-((3-chlorophenyl)methoxy)phenyl)-5-((methylamino)methyl)-
InChi Key
KYXSTSXVEXKFJI-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H19ClN2O3/c1-20-10-17-11-21(18(22)24-17)15-5-7-16(8-6-15)23-12-13-3-2-4-14(19)9-13/h2-9,17,20H,10-12H2,1H3
SMILES Code
O=C1OC(CNC)CN1C2=CC=C(OCC3=CC=CC(Cl)=C3)C=C2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
346.81
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Tipton KF, Fowler CJ, McCrodden JM, Strolin Benedetti M. The enzyme-activated irreversible inhibition of type-B monoamine oxidase by 3-(4-[(3-chlorophenyl)methoxy]phenyl)-5-[(methylamino) methyl]-2-oxazolidinone methanesulphonate (compound MD 780236) and the enzyme-catalysed oxidation of this compound as competing reactions. Biochem J. 1983 Jan 1;209(1):235-42. PubMed PMID: 6847610; PubMed Central PMCID: PMC1154077.
2: Strolin Benedetti M, Dow J. A monoamine oxidase-B inhibitor, MD 780236, metabolized essentially by the A form of the enzyme in the rat. J Pharm Pharmacol. 1983 Apr;35(4):238-45. PubMed PMID: 6133934.
3: Dostert P, Guffroy C, Strolin Benedetti M, Boucher T. Inhibition of semicarbazide-sensitive amine oxidase by monoamine oxidase B inhibitors from the oxazolidinone series. J Pharm Pharmacol. 1984 Nov;36(11):782-5. PubMed PMID: 6150988.
4: Tipton KF, McCrodden JM, Henehan GT, Boucher T, Fowler CJ. The formation of the acidic and alcoholic metabolites of MD 780236. Biochem Pharmacol. 1984 Apr 15;33(8):1377-8. PubMed PMID: 6370268.
5: Dostert P, Strolin Benedetti M, Guffroy C. Different stereoselective inhibition of monoamine oxidase-B by the R- and S-enantiomers of MD 780236. J Pharm Pharmacol. 1983 Mar;35(3):161-5. PubMed PMID: 6132973.
6: Strolin Benedetti M, Dow J, Boucher T, Dostert P. Metabolism of the monoamine oxidase-B inhibitor, MD 780236 and its enantiomers by the A and B forms of the enzyme in the rat. J Pharm Pharmacol. 1983 Dec;35(12):837-40. PubMed PMID: 6141254.
7: Kinemuchi H, Morikawa F, Ueda T, Arai Y. Studies of monoamine oxidase and semicarbazide-sensitive amine oxidase. I. Inhibition by a selective monoamine oxidase-B inhibitor, MD 780236. Jpn J Pharmacol. 1986 Jun;41(2):183-9. PubMed PMID: 3747265.
8: Fuller RW, Wong CJ, Hemrick-Luecke SK. MD 240928 and harmaline: opposite selectivity in antagonism of the inactivation of types A and B monoamine oxidase by pargyline in mice. Life Sci. 1986 Feb 3;38(5):409-12. PubMed PMID: 3945167.
9: Fuller RW, Hemrick-Luecke SK. Influence of selective, reversible inhibitors of monoamine oxidase on the prolonged depletion of striatal dopamine by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. Life Sci. 1985 Sep 23;37(12):1089-96. PubMed PMID: 3875779.
10: Turkish S, Yu PH, Greenshaw AJ. Monoamine oxidase-B inhibition: a comparison of in vivo and ex vivo measures of reversible effects. J Neural Transm. 1988;74(3):141-8. PubMed PMID: 3145323.
11: Benedetti MS, Dostert P, Guffroy C, Tipton KF. Partial or total protection from long-acting monoamine oxidase inhibitors (MAOIs) by new short-acting MAOIs of type A MD780515 and type B MD780236. Mod Probl Pharmacopsychiatry. 1983;19:82-104. PubMed PMID: 6408412.
12: Ding CZ, Silverman RB. Transformation of heterocyclic reversible monoamine oxidase-B inactivators into irreversible inactivators by N-methylation. J Med Chem. 1993 Nov 12;36(23):3606-10. PubMed PMID: 8246228.
