MedKoo Cat#: 563675 | Name: G10 STING agonist
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

G10 is a human-specific STING agonist, triggering IRF3/IFN-associated transcription in human fibroblasts.

Chemical Structure

G10 STING agonist
G10 STING agonist
CAS#702662-50-8

Theoretical Analysis

MedKoo Cat#: 563675

Name: G10 STING agonist

CAS#: 702662-50-8

Chemical Formula: C21H16ClFN2O3S

Exact Mass: 430.0554

Molecular Weight: 430.87

Elemental Analysis: C, 58.54; H, 3.74; Cl, 8.23; F, 4.41; N, 6.50; O, 11.14; S, 7.44

Price and Availability

Size Price Availability Quantity
25mg USD 350.00 2 Weeks
50mg USD 600.00 2 Weeks
100mg USD 950.00 2 Weeks
200mg USD 1,450.00 2 Weeks
500mg USD 2,250.00 2 Weeks
1g USD 3,250.00 2 Weeks
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Related CAS #
No Data
Synonym
G10; G-10; G 10; STING agonist G10; STING Agonist-1; STING agonist-1 (G10)
IUPAC/Chemical Name
4-(2-Chloro-6-fluorobenzyl)-N-(furan-2-ylmethyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide
InChi Key
NAGKYJATVFXZKN-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H16ClFN2O3S/c22-16-4-1-5-17(23)15(16)11-25-18-9-13(6-7-19(18)29-12-20(25)26)21(27)24-10-14-3-2-8-28-14/h1-9H,10-12H2,(H,24,27)
SMILES Code
O=C(C1=CC=C(C(N2CC3=C(F)C=CC=C3Cl)=C1)SCC2=O)NCC4=CC=CO4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 430.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sali TM, Pryke KM, Abraham J, Liu A, Archer I, Broeckel R, Staverosky JA, Smith JL, Al-Shammari A, Amsler L, Sheridan K, Nilsen A, Streblow DN, DeFilippis VR. Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses. PLoS Pathog. 2015 Dec 8;11(12):e1005324. doi: 10.1371/journal.ppat.1005324. eCollection 2015 Dec. PubMed PMID: 26646986; PubMed Central PMCID: PMC4672893.