Losulazine | CAS#72141-57-2 | antihypertensive agent

MedKoo Cat#: 599248 | Name: Losulazine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Losulazine is a new antihypertensive agent.

Chemical Structure

Losulazine

CAS#72141-57-2 (free base)

Theoretical Analysis

MedKoo Cat#: 599248

Name: Losulazine

CAS#: 72141-57-2 (free base)

Chemical Formula: C27H22F4N4O3S

Exact Mass: 558.1349

Molecular Weight: 558.55

Elemental Analysis: C, 58.06; H, 3.97; F, 13.61; N, 10.03; O, 8.59; S, 5.74

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

Losulazine HCl H2O 72141-57-2 (free base) 81435-67-8 (HCl)

Synonym

Losulazine; Losulazina; Losulazinum;

IUPAC/Chemical Name

(4-((4-fluorophenyl)sulfonyl)piperazin-1-yl)(4-((7-(trifluoromethyl)quinolin-4-yl)amino)phenyl)methanone

InChi Key

SYJKIRZBDWNJSB-UHFFFAOYSA-N

InChi Code

InChI=1S/C27H22F4N4O3S/c28-20-4-8-22(9-5-20)39(37,38)35-15-13-34(14-16-35)26(36)18-1-6-21(7-2-18)33-24-11-12-32-25-17-19(27(29,30)31)3-10-23(24)25/h1-12,17H,13-16H2,(H,32,33)

SMILES Code

O=C(N1CCN(S(=O)(C2=CC=C(F)C=C2)=O)CC1)C3=CC=C(NC4=CC=NC5=CC(C(F)(F)F)=CC=C45)C=C3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 558.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Pals DT, DeGraaf GL. Cardiovascular effects of losulazine hydrochloride, a peripheral norepinephrine-depleting agent, in nonhuman primates. J Pharmacol Exp Ther. 1985 Feb;232(2):407-12. PubMed PMID: 3968642. 2: Gore R, Musselman D, Micalizzi E, Slomka M. Losulazine, a new antihypertensive. Clin Pharmacol Ther. 1985 Aug;38(2):195-8. PubMed PMID: 4017421. 3: Pals DT. Hormonal and cardiovascular effects of losulazine hydrochloride in relation to sodium balance in nonhuman primates. Clin Exp Hypertens A. 1986;8(7):1179-88. PubMed PMID: 3533328. 4: Pan JT, Hooth MJ, Lookingland KJ, Moore KE, Marks TA. Comparison of the effects of losulazine and reserpine on central aminergic neurons. Toxicol Appl Pharmacol. 1993 Nov;123(1):26-33. PubMed PMID: 8236258. 5: Mesfin GM, Factor SS, Higgins MJ. Pathologic changes in the accessory sex glands of rats treated with a sympatholytic hypotensive agent (losulazine). Toxicol Pathol. 1989;17(3):516-24. PubMed PMID: 2814227. 6: Mesfin GM, Johnson GA, Higgins MJ, Morris DF. Mechanism of anestrus in rats treated with an antihypertensive agent, losulazine hydrochloride. Toxicol Appl Pharmacol. 1987 Jan;87(1):91-101. PubMed PMID: 3099429. 7: Morris DF, Marks TA, Mesfin GM. Effects of losulazine on rat reproduction and development. Fundam Appl Toxicol. 1987 Oct;9(3):573-87. PubMed PMID: 3692015. 8: Poppe SM, Marks TA, Mesfin GM, Soule DL, Shaw CI, Morris DF, Black DL. Reproductive and developmental effects on rats after prenatal, postnatal, or pre- and postnatal exposure to the hypotensive agent losulazine. Teratology. 1987 Oct;36(2):171-80. PubMed PMID: 3424203. 9: McCall JM, TenBrink RE, Kamdar BV, Skaletzky LL, Perricone SC, Piper RC, Delehanty PJ. 7-(Trifluoromethyl)-4-aminoquinoline hypotensives: novel peripheral sympatholytics. J Med Chem. 1986 Jan;29(1):133-7. PubMed PMID: 3941407. 10: Ray A, Chatterjee S, Biswas NM. Study on the activities of testes and accessory sex glands after losulazine treatment in rats. Toxicol Lett. 1994 Sep;73(3):175-83. PubMed PMID: 8091426. 11: Gray LE Jr, Ostby J, Ferrell J, Sigmon R, Cooper R, Linder R, Rehnberg G, Goldman J, Laskey J. Correlation of sperm and endocrine measures with reproductive success in rodents. Prog Clin Biol Res. 1989;302:193-206; discussion 206-9. Review. PubMed PMID: 2666989.