Synonym
Isopentaquine; SN 13274; SN-13274; SN13274;
IUPAC/Chemical Name
N1-isopropyl-N4-(6-methoxyquinolin-8-yl)pentane-1,4-diamine
InChi Key
FXVNYPZBTGPKQO-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H27N3O/c1-13(2)19-9-5-7-14(3)21-17-12-16(22-4)11-15-8-6-10-20-18(15)17/h6,8,10-14,19,21H,5,7,9H2,1-4H3
SMILES Code
CC(NC1=C2N=CC=CC2=CC(OC)=C1)CCCNC(C)C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
301.43
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: SCHMIDT IG, SCHMIDT LH. Neurotoxicity of the 8-aminoquinolines. III. The effects of pentaquine, isopentaquine, primaquine, and pamaquine on the central nervous system of the rhesus monkey. J Neuropathol Exp Neurol. 1951 Jul;10(3):231-56. PubMed PMID: 14861663.
2: Lewis MD, Behrends J, Sá E Cunha C, Mendes AM, Lasitschka F, Sattler JM, Heiss K, Kooij TW, Prudêncio M, Bringmann G, Frischknecht F, Mueller AK. Chemical attenuation of Plasmodium in the liver modulates severe malaria disease progression. J Immunol. 2015 May 15;194(10):4860-70. doi: 10.4049/jimmunol.1400863. Epub 2015 Apr 10. PubMed PMID: 25862814.
3: ALVING AS. Study of pentaquine and isopentaquine, therapeutic agents effective in reducing relapse rate in vivax malaria. Abstr Int Congr Trop Med Malar. 1948;56(4th Congr):58. PubMed PMID: 18872928.
4: COOPER WC, MYATT AV, HERNANDEZ T, JEFFERY GM, COATNEY GR. Studies in human malaria. XXXI. Comparison of primaquine, isopentaquine, SN-3883, and pamaquine as curative agents against Chesson strain vivax malaria. Am J Trop Med Hyg. 1953 Nov;2(6):949-57. PubMed PMID: 13104803.
5: CHRISTEN R, ATIAS VA. [Trials of chemotherapy in experimental Chagas disease. XI. Action of isopentaquine diphosphate, alone and with quinine sulfate]. Bol Inf Parasit Chil. 1953 Apr-Jun;8(2):30-3. Undetermined Language. PubMed PMID: 13105739.
6: Grewal RS. Pharmacology of 8-aminoquinolines. Bull World Health Organ. 1981;59(3):397-406. PubMed PMID: 6976847; PubMed Central PMCID: PMC2396079.
