S 8666 | CAS#103968-87-2 | diuretic agent

MedKoo Cat#: 461659 | Name: S 8666

Description:

WARNING: This product is for research use only, not for human or veterinary use.

S 8666 is a potent diuretic with uricosuric action.

Chemical Structure

S 8666

CAS#103968-87-2

Theoretical Analysis

MedKoo Cat#: 461659

Name: S 8666

CAS#: 103968-87-2

Chemical Formula: C11H11Cl2NO5S

Exact Mass: 338.9735

Molecular Weight: 340.17

Elemental Analysis: C, 38.84; H, 3.26; Cl, 20.84; N, 4.12; O, 23.52; S, 9.42

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

S 8666; S-8666; S8666;

IUPAC/Chemical Name

6,7-dichloro-5-(N,N-dimethylsulfamoyl)-2,3-dihydrobenzofuran-2-carboxylic acid

InChi Key

ZTFUDCAAHOVUPH-UHFFFAOYSA-N

InChi Code

InChI=1S/C11H11Cl2NO5S/c1-14(2)20(17,18)7-4-5-3-6(11(15)16)19-10(5)9(13)8(7)12/h4,6H,3H2,1-2H3,(H,15,16)

SMILES Code

O=C(C1OC2=C(Cl)C(Cl)=C(S(=O)(N(C)C)=O)C=C2C1)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 340.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Shimizu T, Nakamura M, Imai M. Effect of S-8666 on Cl- transport in the rabbit connecting tubule perfused in vitro. Tohoku J Exp Med. 1991 Aug;164(4):293-8. PubMed PMID: 1746018. 2: Fujimura A, Ohashi K, Ebihara A. Chronopharmacology of the new uricosuric diuretic S-8666 in rats. Jpn J Pharmacol. 1991 May;56(1):105-8. PubMed PMID: 1880979. 3: Yonetani Y, Iwaki K, Shinosaki T, Kawase-Hanafusa A, Harada H, van Es AA. A new uricosuric diuretic, S-8666, in rats and chimpanzees. Jpn J Pharmacol. 1987 Apr;43(4):389-98. PubMed PMID: 3613285. 4: Shimizu T, Nakamura M, Imai M. Renal action of a novel uricosuric diuretic, S-8666. II. Effects on Cl- and urate transport in isolated perfused rabbit renal tubules. J Pharmacol Exp Ther. 1988 May;245(2):651-7. PubMed PMID: 3367311. 5: Fujimura A, Kajiyama H, Ohashi K, Ebihara A. Chronopharmacology of the new uricosuric diuretic S-8666 in rats: (II). Examination in aged rats. Jpn J Pharmacol. 1991 May;56(1):43-51. PubMed PMID: 1880985. 6: Nakano M, Kawahara S. Stereoselective renal tubular secretion of a new uricosuric diuretic, 6,7-dichloro-5-(N,N-dimethylsulfamoyl)-2,3-dihydro-2-benzofurancarboxyl ic acid (S-8666), in cynomolgus monkeys. Drug Metab Dispos. 1992 Mar-Apr;20(2):179-85. PubMed PMID: 1352207. 7: Shimizu T, Itoh T, Nakamura M. Additive diuretic effect of S-8666 during furosemide-induced diuresis in rats. J Pharmacol Exp Ther. 1989 Aug;250(2):659-66. PubMed PMID: 2760848. 8: Yonetani Y, Iwaki K, Ishii M, Harada H. A new diuretic that does not reduce renal handling of uric acid in rats, S-8666. Jpn J Pharmacol. 1987 Apr;43(4):399-405. PubMed PMID: 3613286. 9: Shimizu T, Miyata K, Nakamura M. Effect of S-8666 on urinary Ca++ excretion in rats. J Pharmacol Exp Ther. 1989 Aug;250(2):654-8. PubMed PMID: 2760847. 10: Shimuizu T, Nakamura M, Imai M. Renal action of a novel uricosuric diuretic, S-8666. I. Clearance and tubular microinjection studies in rats. J Pharmacol Exp Ther. 1988 May;245(2):644-50. PubMed PMID: 3367310. 11: Higaki K, Nakano M. Stereoselective disposition of S-8666, a novel uricosuric antihypertensive diuretic, and its N-monodemethylated metabolite in a perfused rat liver preparation. Effect of protein binding on the kinetics of S-8666. Drug Metab Dispos. 1992 May-Jun;20(3):350-5. PubMed PMID: 1355707. 12: Higaki J, Hirata M. Stereoselective glutathione conjugation of a uricosuric diuretic. Chem Biol Interact. 1989;72(1-2):209-14. PubMed PMID: 2582543. 13: Shinosaki T, Yonetani Y. Stop-flow studies on tubular transport of uric acid in rats. Adv Exp Med Biol. 1989;253A:293-300. PubMed PMID: 2624206. 14: Nakano M, Higaki K, Kawahara S. Enantiomer-enantiomer interaction of a uricosuric antihypertensive diuretic (DBCA) in renal tubular secretion and stereoselective inhibition by probenecid in the cynomolgus monkey. Xenobiotica. 1993 May;23(5):525-36. PubMed PMID: 8342300. 15: Higaki K, Kadono K, Goto S, Nakano M. Stereoselective renal tubular secretion of an organic anion in the isolated perfused rat kidney. J Pharmacol Exp Ther. 1994 Jul;270(1):329-35. PubMed PMID: 8035328. 16: Higaki K, Kadono K, Nakano M. Stereoselective pharmacokinetics of a novel uricosuric antihypertensive diuretic in rats: pharmacokinetic interaction between enantiomers. J Pharm Sci. 1992 Sep;81(9):935-9. PubMed PMID: 1432643. 17: Nakano M, Kawahara S. High-performance liquid chromatographic method for simultaneous determination of enantiomers of 5-dimethylsulphamoyl-6,7-dichloro-2-dihydrobenzofuran-2, carboxylic acid and its N-monodemethyl metabolite in monkey plasma and urine after chiral derivatization. J Chromatogr. 1991 Mar 8;564(1):235-41. PubMed PMID: 1860916. 18: Higaki J, Kikuchi J, Ikenishi Y, Hirata M. Structure determination of a diuretic-glutathione conjugate by mass and n.m.r. spectrometry. Xenobiotica. 1991 Jan;21(1):47-51. PubMed PMID: 2003366. 19: Kariya K, Okumura H, Lee E, Hirata M. Stereoselective conjugation of a uricosuric diuretic with glutathione by glutathione transferase 3-3. Xenobiotica. 1992 Mar;22(3):319-23. PubMed PMID: 1496822.