MedKoo Cat#: 592812 | Name: Amidantel hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Amidantel hydrochloride is a new aminophenylamidine with an interesting anthelminthic spectrum. In rodents the compound is active against nematodes, filariae and cestodes. Of special interest is the high efficacy in dogs against hookworms and large roundworms. Amidantel was well tolerated by all animals tested and did not show teratogenic effects.

Chemical Structure

Amidantel hydrochloride
Amidantel hydrochloride
CAS#69884-15-7 (HCl)

Theoretical Analysis

MedKoo Cat#: 592812

Name: Amidantel hydrochloride

CAS#: 69884-15-7 (HCl)

Chemical Formula: C13H20ClN3O2

Exact Mass: 285.1244

Molecular Weight: 285.77

Elemental Analysis: C, 54.64; H, 7.05; Cl, 12.40; N, 14.70; O, 11.20

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
BAY d 8815; BAY-d 8815; Amidantel hydrochloride
IUPAC/Chemical Name
Acetamide, N-(4-((1-(dimethylamino)ethylidene)amino)phenyl)-2-methoxy-, hydrochloride
InChi Key
FMCZRVAXIJNEDS-KMZJGFRYSA-N
InChi Code
InChI=1S/C13H19N3O2.ClH/c1-10(16(2)3)14-11-5-7-12(8-6-11)15-13(17)9-18-4;/h5-8H,9H2,1-4H3,(H,15,17);1H/b14-10+;
SMILES Code
O=C(NC1=CC=C(/N=C(N(C)C)\C)C=C1)COC.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 285.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Pejo E, Santer P, Jeffrey S, Gallin H, Husain SS, Raines DE. Analogues of etomidate: modifications around etomidate's chiral carbon and the impact on in vitro and in vivo pharmacology. Anesthesiology. 2014 Aug;121(2):290-301. doi: 10.1097/ALN.0000000000000268. PubMed PMID: 24777068; PubMed Central PMCID: PMC4121658. 2: Bruder EA, Ball IM, Ridi S, Pickett W, Hohl C. Single induction dose of etomidate versus other induction agents for endotracheal intubation in critically ill patients. Cochrane Database Syst Rev. 2015 Jan 8;1:CD010225. doi: 10.1002/14651858.CD010225.pub2. Review. PubMed PMID: 25568981. 3: Liu HC, Zhu D, Wang C, Guan H, Li S, Hu C, Chen Z, Hu Y, Lin H, Lian QQ, Ge RS. Effects of Etomidate on the Steroidogenesis of Rat Immature Leydig Cells. PLoS One. 2015 Nov 10;10(11):e0139311. doi: 10.1371/journal.pone.0139311. eCollection 2015. PubMed PMID: 26555702; PubMed Central PMCID: PMC4640886. 4: Liu S, Zhang XP, Han NN, Lv S, Xiong JY. Pretreatment with low dose etomidate prevents etomidate-induced rat adrenal insufficiency by regulating oxidative stress-related MAPKs and apoptosis. Environ Toxicol Pharmacol. 2015 May;39(3):1212-20. doi: 10.1016/j.etap.2015.04.014. Epub 2015 Apr 25. PubMed PMID: 25989534. 5: Song JC, Lu ZJ, Jiao YF, Yang B, Gao H, Zhang J, Yu WF. Etomidate Anesthesia during ERCP Caused More Stable Haemodynamic Responses Compared with Propofol: A Randomized Clinical Trial. Int J Med Sci. 2015 Jul 3;12(7):559-65. doi: 10.7150/ijms.11521. eCollection 2015. PubMed PMID: 26180512; PubMed Central PMCID: PMC4502060. 6: Hinkewich C, Green R. The impact of etomidate on mortality in trauma patients. Can J Anaesth. 2014 Jul;61(7):650-5. doi: 10.1007/s12630-014-0161-6. Epub 2014 Apr 11. PubMed PMID: 24723214. 7: Erdoes G, Basciani RM, Eberle B. Etomidate--a review of robust evidence for its use in various clinical scenarios. Acta Anaesthesiol Scand. 2014 Apr;58(4):380-9. doi: 10.1111/aas.12289. Epub 2014 Mar 3. Review. PubMed PMID: 24588359. 8: Shen XC, Ao X, Cao Y, Lan L, Liu XM, Sun WJ, Li P, Lan CH. Etomidate-remifentanil is more suitable for monitored anesthesia care during gastroscopy in older patients than propofol-remifentanil. Med Sci Monit. 2015 Jan 1;21:1-8. doi: 10.12659/MSM.891183. PubMed PMID: 25553506; PubMed Central PMCID: PMC4288392. 9: Ayhan Y, Akbulut BB, Karahan S, Gecmez G, Öz G, Gurel SC, Basar K. Etomidate is associated with longer seizure duration, lower stimulus intensity, and lower number of failed trials in electroconvulsive therapy compared with thiopental. J ECT. 2015 Mar;31(1):26-30. doi: 10.1097/YCT.0000000000000149. PubMed PMID: 24901431. 10: Souvatzis X, Kalogridaki M, Mavrakis HE, Kanoupakis EM, Marouli D, Vardas P, Askitopoulou H. Adding fentanyl to etomidate fails to reduce painful recall of external direct current cardioversion in adults: a randomised trial. Hellenic J Cardiol. 2015 Mar-Apr;56(2):142-8. PubMed PMID: 25854443. 11: Raksakietisak M, Ngamlamiad C, Duangrat T, Soontarinka S, Raksamani K. The Changes in Cortisol Levels during Cardiac Surgery: A Randomized Double-Blinded Study between Two Induction Agents Etomidate and Thiopentone. J Med Assoc Thai. 2015 Aug;98(8):775-81. PubMed PMID: 26437535. 12: Yu JB, Dong SA, Gong LR, Wang M, Mu R, Li C, Zhang Y, Li ZD. Effect of electroacupuncture at Zusanli (ST36) and Sanyinjiao (SP6) acupoints on adrenocortical function in etomidate anesthesia patients. Med Sci Monit. 2014 Mar 12;20:406-12. doi: 10.12659/MSM.890111. PubMed PMID: 24621826; PubMed Central PMCID: PMC3958570. 13: Smischney NJ, Hoskote SS, Gallo de Moraes A, Racedo Africano CJ, Carrera PM, Tedja R, Pannu JK, Hassebroek EC, Reddy DR, Hinds RF, Thakur L. Ketamine/propofol admixture (ketofol) at induction in the critically ill against etomidate (KEEP PACE trial): study protocol for a randomized controlled trial. Trials. 2015 Apr 21;16:177. doi: 10.1186/s13063-015-0687-0. PubMed PMID: 25909406; PubMed Central PMCID: PMC4409710. 14: Shanmugasundararaj S, Zhou X, Neunzig J, Bernhardt R, Cotten JF, Ge R, Miller KW, Raines DE. Carboetomidate: an analog of etomidate that interacts weakly with 11β-hydroxylase. Anesth Analg. 2013 Jun;116(6):1249-56. doi: 10.1213/ANE.0b013e31828b3637. Epub 2013 Mar 14. PubMed PMID: 23492967; PubMed Central PMCID: PMC3836822. 15: Azimaraghi O, Aghajani Y, Molaghadimi M, Khosravi M, Eslami K, Ghadimi F, Movafegh A. Ondansetron reducing pain on injection of etomidate: a controlled randomized study. Braz J Anesthesiol. 2014 May-Jun;64(3):169-72. doi: 10.1016/j.bjane.2013.06.013. Epub 2013 Oct 23. PubMed PMID: 24907875. 16: Alday NJ, Jones GM, Kimmons LA, Phillips GS, McCallister JW, Doepker BA. Effects of etomidate on vasopressor use in patients with sepsis or severe sepsis: a propensity-matched analysis. J Crit Care. 2014 Aug;29(4):517-22. doi: 10.1016/j.jcrc.2014.02.002. Epub 2014 Feb 14. PubMed PMID: 24629575. 17: Witeska M, Dudyk J, Jarkiewicz N. Haematological effects of 2-phenoxyethanol and etomidate in carp (Cyprinus carpio L.). Vet Anaesth Analg. 2015 Sep;42(5):537-46. doi: 10.1111/vaa.12242. Epub 2014 Dec 29. PubMed PMID: 25545607. 18: Rech MA, Bennett S, Chaney W, Sterk E. Risk factors for mortality in septic patients who received etomidate. Am J Emerg Med. 2015 Oct;33(10):1340-3. doi: 10.1016/j.ajem.2015.07.062. Epub 2015 Jul 29. PubMed PMID: 26321168. 19: Canbek O, Ipekcıoglu D, Menges OO, Atagun MI, Karamustafalıoglu N, Cetinkaya OZ, Ilnem MC. Comparison of Propofol, Etomidate, and Thiopental in Anesthesia for Electroconvulsive Therapy: A Randomized, Double-blind Clinical Trial. J ECT. 2015 Jun;31(2):91-7. doi: 10.1097/YCT.0000000000000190. PubMed PMID: 25268043. 20: Weng D, Huang M, Jiang R, Zhan R, Yang C. Clinical study of etomidate emulsion combined with remifentanil in general anesthesia. Drug Des Devel Ther. 2013 Aug 20;7:771-6. doi: 10.2147/DDDT.S45979. eCollection 2013. PubMed PMID: 23990706; PubMed Central PMCID: PMC3753064.