Locustamyotropin | CAS#129192-62-7 | novel peptide

MedKoo Cat#: 599143 | Name: Locustamyotropin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Locustamyotropin is a novel peptide isolated from Leucophae maderae; stimulates the spontaneous contractions of the hindgut of Leucophaea maderae.

Chemical Structure

Locustamyotropin

CAS#129192-62-7

Theoretical Analysis

MedKoo Cat#: 599143

Name: Locustamyotropin

CAS#: 129192-62-7

Chemical Formula: C55H89N17O14

Exact Mass: 1211.6775

Molecular Weight: 1212.42

Elemental Analysis: C, 54.49; H, 7.40; N, 19.64; O, 18.47

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Locustamyotropin; Lom-MT; Lom MT; LomMT; Gly-ala-val-pro-ala-ala-gln-phe-ser-pro-arg-leu-NH2; Locustamyotropin I;

IUPAC/Chemical Name

(S)-N1-((S)-1-(((S)-1-((S)-2-(((S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)carbamoyl)pyrrolidin-1-yl)-3-hydroxy-1-oxopropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-((S)-2-((S)-1-(glycyl-L-alanyl-L-valyl)pyrrolidine-2-carboxamido)propanamido)propanamido)pentanediamide

InChi Key

NPNBMKDPZYWGOL-LSMZMZNBSA-N

InChi Code

InChI=1S/C55H89N17O14/c1-28(2)24-36(44(58)76)67-48(80)34(16-11-21-61-55(59)60)66-52(84)40-18-12-22-71(40)53(85)38(27-73)69-50(82)37(25-33-14-9-8-10-15-33)68-49(81)35(19-20-41(57)74)65-46(78)32(7)63-45(77)31(6)64-51(83)39-17-13-23-72(39)54(86)43(29(3)4)70-47(79)30(5)62-42(75)26-56/h8-10,14-15,28-32,34-40,43,73H,11-13,16-27,56H2,1-7H3,(H2,57,74)(H2,58,76)(H,62,75)(H,63,77)(H,64,83)(H,65,78)(H,66,84)(H,67,80)(H,68,81)(H,69,82)(H,70,79)(H4,59,60,61)/t30-,31-,32-,34-,35-,36-,37-,38-,39-,40-,43-/m0/s1

SMILES Code

C[C@H](NC(CN)=O)C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N2CCC[C@H]2C(N[C@H](C(N[C@H](C(N)=O)CC(C)C)=O)CCCNC(N)=N)=O)=O)CO)=O)Cc3ccccc3)=O)CCC(N)=O)=O)C)=O)C)=O)=O)C(C)C)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,212.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Schoofs L, Tips A, Holman GM, Nachman RJ, De Loof A. Distribution of locustamyotropin-like immunoreactivity in the nervous system of Locusta migratoria. Regul Pept. 1992 Feb 18;37(3):237-54. PubMed PMID: 1557513. 2: Schoofs L, Holman GM, Hayes TK, Tips A, Nachman RJ, Vandesande F, De Loof A. Isolation, identification and synthesis of locustamyotropin (Lom-MT), a novel biologically active insect peptide. Peptides. 1990 May-Jun;11(3):427-33. PubMed PMID: 1974346. 3: Isaac R, Schoofs L, Williams TA, Veelaert D, Sajid M, Corvol P, Coates D. A novel peptide-processing activity of insect peptidyl-dipeptidase A (angiotensin I-converting enzyme): the hydrolysis of lysyl-arginine and arginyl-arginine from the C-terminus of an insect prohormone peptide. Biochem J. 1998 Feb 15;330 ( Pt 1):61-5. PubMed PMID: 9461491; PubMed Central PMCID: PMC1219108. 4: Abernathy RL, Nachman RJ, Teal PE, Yamashita O, Tumlinson JH. Pheromonotropic activity of naturally occurring pyrokinin insect neuropeptides (FXPRLamide) in Helicoverpa zea. Peptides. 1995;16(2):215-9. PubMed PMID: 7784251. 5: Veelaert D, Schoofs L, Verhaert P, De Loof A. Identification of two novel peptides from the central nervous system of the desert locust, Schistocerca gregaria. Biochem Biophys Res Commun. 1997 Dec 18;241(2):530-4. PubMed PMID: 9425305. 6: Bräunig P, Böhme C, Staufer B. Morphology of locust neurosecretory cells projecting into the Nervus corporis allati II of the suboesophageal ganglion. Microsc Res Tech. 1996 Oct 15;35(3):230-41. PubMed PMID: 8956272. 7: Houard X, Williams TA, Michaud A, Dani P, Isaac RE, Shirras AD, Coates D, Corvol P. The Drosophila melanogaster-related angiotensin-I-converting enzymes Acer and Ance--distinct enzymic characteristics and alternative expression during pupal development. Eur J Biochem. 1998 Nov 1;257(3):599-606. PubMed PMID: 9839949. 8: Kuniyoshi H, Nagasawa H, Ando T, Suzuki A, Nachman RJ, Holman GM. Cross-activity between pheromone biosynthesis activating neuropeptide (PBAN) and myotropic pyrokinin insect peptides. Biosci Biotechnol Biochem. 1992 Jan;56(1):167-8. PubMed PMID: 1368132.